摘要
The dynamic changes of liver microsomal drug-metabolizing system (MDMS) andlipoperoxidation were studied in scalded rats. The effects of treatment with vitamin E and silybinwere also evaluated. The results showeed that liver microsomal cytochrome P-450 content, and p-nitroanisole demethylase (P-NOD) and aniline hydroxylase (AH) activity decreased markedlypostburn. On the contrary, liver lipoperoxide and mierosomal lipoperoxidation increased significantlyafter scalding. Both the increase of liver lipoperoxide and mierosomal lipoperoxidation and the de-crease of MDMS activity were prevented by vitamin E and silybin treatments.
The dynamic changes of liver microsomal drug-metabolizing system (MDMS) and lipoperoxidation were studied in scalded rats. The effects of treatment with vitamin E and silybin were also evaluated. The results showeed that liver microsomal cytochrome P-450 content, and p- nitroanisole demethylase (P-NOD) and aniline hydroxylase (AH) activity decreased markedly postburn. On the contrary, liver lipoperoxide and mierosomal lipoperoxidation increased significantly after scalding. Both the increase of liver lipoperoxide and mierosomal lipoperoxidation and the de- crease of MDMS activity were prevented by vitamin E and silybin treatments.
