摘要
目的：探讨脑出血患者血浆血小板α颗粒膜蛋白（ＧＭＰ１４０）含量的变化和临床意义。方法：用放射免疫分析法测定９０例脑出血患者和７０例正常人血浆ＧＭＰ１４０的含量。结果：脑出血患者血浆ＧＭＰ１４０含量于发病１周内达高峰〔（２６．５４±７．２１）μｇ／Ｌ〕，明显高于正常对照组〔（９．０２±２．８９）μｇ／Ｌ，Ｐ＜０．０１〕，以后逐渐下降，第３周末多数降为正常〔（９．６５±３．４０）μｇ／Ｌ〕。出血量＞５０ｍｌ组血浆ＧＭＰ１４０含量〔（３９．５８±７．２９）μｇ／Ｌ〕显著高于出血量＜２０ｍｌ组〔（１５．３５±３．９０）μｇ／Ｌ，Ｐ＜０．０１〕；重型组血浆ＧＭＰ１４０含量〔（３２．１８±６．８１）μｇ／Ｌ〕明显高于轻型组〔（１３．０２±３．２１）μｇ／Ｌ，Ｐ＜０．０１〕；恶化死亡组血浆ＧＭＰ１４０含量〔（３３．３１±８．４５）μｇ／Ｌ〕明显高于治愈组〔（１４．６５±５．３４）μｇ／Ｌ，Ｐ＜０．０１〕。结论：测定脑出血患者血浆ＧＭＰ１４０含量可作为临床上估计出血量、监测病情和判断预后的一个指标。
Objective:To explore the changes in plasma platelet αgranule membrane protein140(GMP140) contents in patients with cerebral hemorrhage.Methods:The plasma GMP140 content was determined by radioimmunoassay in 90 cases of cerebral hemorrhage and 70 normal controls.Results:The plasma GMP140 content in cerebral hemorrhage group peaked within 7 days 〔(2654±721)μg/L〕,and it was significantly higher than that in normal controls 〔(902±289)μg/L,P<001〕,then decreased slowly and returned to normal range 3 weeks later 〔(965±340)μg/L〕.Of the patients whose bleeding volume exceeding 50 ml,the GMP140 content was significantly different from that of the patients whose bleeding volume less than 20 ml〔(3958±729)μg/L vs.(1535±390)μg/L,P<001〕.Furthermore,plasma GMP140 content in severe group was significantly higher than that in mild group 〔(3218±681)μg/L vs.(1302±321)μg/L,P<001〕.Additionally,it was markedly higher in nonsurvivors compared to survivors 〔(3331±845)μg/L vs.(1465±534)μg/L,P<001〕.Conclusions:It is suggested that the measurement of plasma GMP140 content in patients with cerebral hemorrhage may be a useful marker for estimating the bleeding volume,monitoring patient′s condition and judging prognosis.
出处
《中国危重病急救医学》
CAS
CSCD
1998年第4期224-226,共3页
Chinese Critical Care Medicine
关键词
脑出血
GMP-140
预后
出血量
cerebral hemorrhage\ \ platelet αgranule membrane protein140
