摘要
目的研究交联聚乙烯基吡咯烷酮水凝胶与硅橡胶共混，形成可自行膨胀的复合材料的可行性。方法将不同比例的复合材料植入24只新西兰白兔背部及鼻背皮下，与硅胶假体比较观察膨胀状况，和机体的反应及复合材料自行软组织扩张的效果。结果通过200d的连续观察，植入兔子皮下的复合材料按照设计膨胀量膨胀，与硅胶材料对比有明显的膨胀性，在一定的时间内最终达到平衡静止；通过组织切片检查，复合材料的周围组织的炎性反应和排斥反应与硅胶相同，上皮基底细胞的有丝分裂活跃。结论可自行膨胀的交联聚乙烯基吡咯烷酮硅橡胶复合材料具有优于硅胶的自行扩张膨胀性能，从而达到扩张软组织的目的。
Objective To study the feasibility of Polyvinylpolypyrrolidone （PVPP）/silieone composite automatic expanded material as implants. Methods The PVPP hydrogel was mixed with silicone through the thioloeation at the high temperature. Implants with different ratio of PVPP to silicone were placed under the back and nose skin in 24 New Zealand rabbits. The surrounding tissue reaction, material and skin expansion were observed and compared with those with pure silicone implants. Results The study lasted for 200 days. Compared with pure silicone implants, the composite material could expand automatically and stop expanding at about 2 weeks after implantation. Histological study showed similar infectional and foreign body reaction around the composite material and the pure silicone. Conclusions Compared with pure silicone, the PVPP/silicone composite implant has the advantage of automatic expansion, so as to expand the soft tissue.
出处
《中华整形外科杂志》
CAS
CSCD
北大核心
2009年第2期140-143,共4页
Chinese Journal of Plastic Surgery
关键词
交联聚乙烯基吡咯烷酮
复合材料
自行膨胀
Polyvinylpolypyrrolidone, PVPP
Composite implant
Automatic expansion
