摘要
给小鼠腹腔注射（ｉｐ）顺铂（ＣＤＤＰ）０５、１０和１５ｍｇ／ｋｇ，每天１次，连续７天，结果显示，骨髓中多染红细胞（ＰＣＥ）微核率显著增高，呈剂量依赖关系，ＰＣＥ百分数则明显下降。给大鼠ｉｐＣＤＤＰ１０ｍｇ／ｋｇ，或ｉｐＣＤＤＰ前灌胃（ｐｏ）水飞蓟宾（ＳＢ，４０ｍｇ／ｋｇ），每天１次，连续７天。结果显示，停药后第２、５天ＣＤＤＰ组与ＣＤＤＰ＋ＳＢ组ＰＣＥ微核率明显增高，停药后第１０天，增高的ＰＣＥ微核率明显下降；而ＰＣＥ百分比则明显回升。ＳＢ对ＣＤＤＰ所致大鼠微核效应无预防作用。
The microucleus formation in polychromatic erythrocyte(PCE)induced by cisplatin(CDDP)was studied in mice and rats.An increase in the number of micronucleated PCE was seen at ip CDDP 05、10 and 15 mg/kg,with dose-effect relationship and a decrease of PCE percentage was seen at ip CDDP 10 and 15 mg/kg in mice.A significant increase of micronucleated PCE was observed at day 2 and 5,but increased micronucleated PEC was decreased at day 10 after ip CDDP 10 mg/kg daily for 7 days in rats.Preventive effect of silybin(SB)(po,40 mg/kg)on increased micronucleated PCE imduced by CDDP was not observed,but SB could increase decreased PCE percentage.
出处
《大连医科大学学报》
CAS
1998年第1期27-29,共3页
Journal of Dalian Medical University
