摘要
目的观察补肾方治疗肝肾亏虚兼湿热型慢性乙型肝炎的临床疗效。方法选取肝肾亏虚兼湿热型慢性乙型肝炎患者共60例,随机分为补肾方治疗组和苦参素对照组各30例,疗程6个月,并随访6个月。观察两组患者血清HBV DNA阴转率、HBeAg阴转率、HBV DNA滴度变化及肝功能、中医证候积分变化。结果治疗组随访时HBV DNA滴度下降较对照组明显(P<0.05);半年疗程结束时治疗组肝功能指标改善(P<0.01,P<0.05),其中TBIL、GLB的改善较对照组明显(P<0.01);治疗组中医证候疗效优于对照组,差异有统计学意义(P<0.05)。结论补肾方治疗肝肾亏虚兼湿热型慢性乙型肝炎有较为明确的抗病毒疗效,且能改善肝功能及临床症状。
Objective To observe the efficacy of ＂Kidney-Invigorating Prescription＂ in treating chronic hepatitis B differentiated as liver-kidney insufficiency accompanied by dampness-heat retention. Methods A total of 60 were enrolled. They were randomized to receive either ＂Kidney-Invigorating Prescription＂ daily （ the treatment group, n =30 ） or Marine Injection 400 mg daily （ control group, n =30 ） for six months, and were followed up for six months. Negative transforming rate of HBV DNA and and HBeAg, titer of HBVDNA, indicators of liver function, and score of TCM syndrome were detected. Results The titer of serum HBVDNA in the treatment group decreased significantly compared with those in the control group （P 〈0.05 ） in the follow-up duration. Meanwhile, ＂Kidney-Invigorating Prescription＂ therapy contributed to the improvement of indicators of liver function, especially SB and GLB, which improved more significantly than in the control group （P 〈0.01 ）. The total effective rate of TCM syndrome in the treatment group was superior to that in the control group（P 〈0.05）. Conclusion Long-term HBV replication suppression and improvment of liver function and symptom can be obtained after treatment by ＂Kidney-Invigorating Prescription＂.
出处
《上海中医药杂志》
2009年第4期33-35,共3页
Shanghai Journal of Traditional Chinese Medicine
基金
浦东新区科技发展基金科技专项基金项目(PKG2005-31)
浦东新区中医中青年骨干培养基金项目(PWZ2008-q03)
关键词
慢性乙型肝炎
补肾方
苦参素
血清病毒学
中医证候
临床研究
Chronic hepatitis B
＂Kidney-Invigorating Prescription＂
marine
serum virology
syndrome of Chinese medicine
clinical study
