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肝性脑病的基础与临床研究进展 被引量：10

The advance of hepatic encephalopathy in basal and clinical research
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摘要 肝性脑病是肝病患者常见的并发症和死亡原因,近年来对于肝性脑病的研究无论在发病机制、临床诊断还是治疗方面均取得了很大进展,本文对此各方面内容进行综述以期对广大肝病工作者有所帮助。 Hepatic encephalopathy is the most frequently complaint and death reasons of hepatic diseases. Recently the pathology, diagnosis and treatment of hepatic encephalophathy made many efforts. The article reviews all the above and helps hepatic medical workers in clinical.
作者 胡颖
机构地区 上海交通大学医学院附属新华医院消化内科
出处 《胃肠病学和肝病学杂志》 CAS 2009年第4期291-294,共4页 Chinese Journal of Gastroenterology and Hepatology
关键词 肝脏疾病 脑病 肝性脑病 基础研究 临床研究 Liver disease Encephalopathy Hepatic encephalopathy Basal research Clinical research
分类号 R575.3 [医药卫生—消化系统]
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参考文献15

  • 1Ferenci P, Lockwood A, Mullen K, et al. Hepatic encephalopathy-definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11 th World Congresses of Gastroenterology, Vienna, 1998 [J]. Hepatology, 2002, 35 (3): 716-721.
  • 2Blei A T, Cordoba J. Hepatic eneephalopathy [ J]. Am J Gastroenterol, 2001, 96(4) : 1968-1976.
  • 3Hazell AS, Butterworth RF. Hepatic encephalopathy: an update of pathophysiologic : mechanisms [ J]. Pro Sec Ex Med, 1999, 222(2) : 99-112.
  • 4Jones EA. Ammonia, the GABA neurotransmitter system, and hepatic encephalopathy[J]. Metab Brain Dis, 2002, 17 (4): 275-281.
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  • 6Rama Rao KV, Chen M, Simard JM, et al. Increased aquaporin-4 expression in ammonia-treated cultured astrocytes [ J ]. Neuroreport, 2003, 14 ( 18 ) : 2379-2382.
  • 7Rama Rao KV, Jayakumar AR, Norenberg MD. Differential response of glutamine in cultured neuronsandastrocytes [ J]. J Neurosci Res, 2005, 79(1-2) : 193-199.
  • 8HaMai D, Campbell A, Bondy SC. Modulation of oxidative events by muhivalent manganese complexes in brain tissue [ J]. Free Radic Biol Med, 2001, 31 (6): 763-768.
  • 9Fernandez-gomez FJ, Galindo MF, Gomez-lazaro M, et al. Malonate induces cell death via mitochondrial potential collapse and delayed swelling through an ROS-dependent pathway [ J ]. Br J Phamacol, 2005, 144(4) : 528-537.
  • 10Kircheis G, Wettstein M, Timmermann L, et al. Critical flicker frequency for quantification of low-grade hepatic encephalopathy [ J ]. Hepatology, 2002, 35 (2) : 357-366.

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胃肠病学和肝病学杂志
2009年 第4期

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