摘要
为了进一步探讨药疹的发病机理和提供新的治疗途径，应用CoatronⅣ型血液凝固仪及酶联免疫吸附试验、火箭电泳法测定71例药疹患者凝血及抗凝血功能，其中多形红斑型。紫癜型及剥脱性皮炎型APTT较对照组明显缩短，紫癜型及剥脱性皮炎型PT明显缩短（P＜0,01，P＜0,05），A－Ⅲ明显减低，D-dimer显著增高,表明重症药疹时凝血及抗凝血之间的平衡失常。当肝肾功能障碍时，要注意血栓前状态。警惕DIC的发生,
For the purposes study of the mechanism of drug eruption and to provide a new approach for its treatment,authors determined the functional state of coagulation and anticoagulation system by Coatron type IV blood coagulate instrument and ELISA,rocket electrophoresis in 71 cases of drug erilptions. The time of part of coagulatase in erythema multitorme type (APTT) was shortened (P<0.01). The prothrombin time (PT) of purpuric and exfoliative dermatitis type. .APTT were shortened in compared with the control group (P<0.01. P<0. 05). The antithrombin Ⅲ (AT-Ⅲ) was decrease (P<0.01). The D-dimer was increased (P<0.01). It means that the balance of co-agulation and anticoagulation systems were abnormal in the severe drug eruption patients.All the results showed must pay more attention to the prethrombotic state. watch out for the DIC happens as the patients hepatic and renal functions impaired.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
1998年第2期83-84,共2页
Journal of Clinical Dermatology
关键词
药物性皮炎
凝血
抗凝血系统
Drug eruption Coagulation Prethrombotic state
