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MicroRNAs与肿瘤 被引量：1

MicroRNAs and Cancer
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摘要 microRNA(miRNA)是一类对基因具有调控功能的内源性非编码小分子RNA,通过与靶mRNA完全或不完全互补配对,引起mRNA降解或翻译抑制,从而对基因转录后水平进行调控。目前认为miRNA在多种生物学过程中起着至关重要的作用,包括细胞增殖、分化、凋亡等。研究显示miRNA的表达异常能导致疾病甚至肿瘤的发生,有类似于抑癌基因或癌基因的功能。本文就miRNA在肿瘤发生和诊断方面的研究进展作一综述。 MicroRNA （miRNA） is a family of endogenous, non-coding small RNAs molecules weighting about 22 nucleotides that function as gene regulators. They can repress target genes expression at the post-transcriptional level by base pairing to the 3＇unstranlated region of multiple target messenger RNAs. Pioneering studies described miRNA may play a critical role in many biological processes including cell proliferation, differentiation and apoptosis. It is now apparent that aberrant expression of miRNAs can lead to several human diseases including cancer. These tiny but potent molecules have the function as anti-oncogene or oncogene. In this review, we have summarized the research ofmiRNA in tumorigenesis and diagnosis.
作者 陈滔 贺修胜
机构地区 南华大学肿瘤研究所
出处 《现代生物医学进展》 CAS 2009年第7期1362-1364,共3页 Progress in Modern Biomedicine
基金 国家自然科学基金(30470967) 湖南省高等学校科学研究重点项目(08A060)。
关键词 microRNA(miRNA) 非编码小RNA 肿瘤 microRNA（miRNA） Non-coding small RNA Cancer
分类号 R730 [医药卫生—肿瘤]
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参考文献21

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同被引文献11

  • 1季菊玲,张锦生.microRNA与肿瘤[J].中华病理学杂志,2006,35(10):628-630. 被引量：6
  • 2Karres JS,Hilgers V,Carrera I,et al.The conserved microRNA miR28 tunes atrophin levels to prevent neurodegeneration in drosophila.Cell,2007,131(1):136-145.
  • 3Bartel DP.MicroRNAs:genomics,biogenesis,mechanism,and function.Cell,2004,116:281-297.
  • 4Papagiannakopoulos T,Kosik KS.MicroRNAs:regulators of oncogenesis and stemness.BMC Medicine,2008,6:15.
  • 5Ryazansky SS,Gvozdev VA.Small RNAs and Cancerogenesis.Biochemistry (Mosc),2008,73(5):514-527.
  • 6Esquela,Kerscher A,Slack FJ.Oncom irsm icroRNAs with a role in cancer.Nat Rev Cancer,2006,6(4):259-269.
  • 7Slack FJ,Weidhaas JB.MicroRNAs as a potential magic bullet in cancer.Fut Oncol,2006,2(1):73-82.
  • 8Lewis BP,Shih IH,Rhoades MW,et al.Prediction of malian microRNA targets.Cell,2003,115(7):787-798.
  • 9O'Donnell KA,Wentzel EA,Zeller KI,et al.Mycoregulated microRNAs modulate EF1 expression.Nature,2005,435(7043):839-843.
  • 10HE L,Thomson JM,Hemannm T,et al.microRNA poly cistron as a potential human oncogene.Nature,2005,435:828-833.

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现代生物医学进展
2009年 第7期

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