摘要
目的:观察糖骨康对糖尿病骨质疏松患者骨密度(BMD)、空腹血糖(FBG)、糖化血红蛋白(HbA1 c)和血清骨钙素(BGP)、骨碱性磷酸酶(BALP)、胰岛素样生长因子-1(IGF-1)以及24h尿蛋白(PRO)、尿钙(Ca)、尿磷(P)含量的影响。方法:将139例糖尿病骨质疏松患者随机分为治疗组74例,对照组65例,治疗组服用中药糖骨康汤剂,对照组服用盖天力片,30天为1疗程,治疗前后检测BMD、FBG、HbA1 c和血清BGP、BALP、IGF-1以及尿PRO、Ca、P的变化。结果:治疗后两组BMD和血清BGP、IGF-1显著上升(P<0.05或P<0.01),FBG、HbA1 c、BALP和尿PRO、Ca、P含量显著下降(P<0.05或P<0.01),治疗组在升高BMD和降低BALP、尿Ca、P含量方面优于对照组(P<0.05)。结论:糖骨康可降低糖尿病骨质疏松患者血糖,调节骨代谢相关因子,减少尿钙磷的排泄,减轻骨质疏松。
Objectior：To observe the effect of Tanggukang on bone density（BMD）,fasting blood glucose（FBG）,glycosylated hemoglobin（HbA1c）,the content of bone gla protein（BGP）,bone alkaline phosphatase（BALP）,insulin-like growth factor （IGF-1） in the serum and calcium（Ca）,phosphours（P）,Urine protein（PRO）in urine of patients of type 2 diabetes with osteoporos.Methods：139 cases patients of type 2 diabetes with osteoporos were devided into two groups,the treatment group（n=74）were treated by Tanggukang,and control group（n=65） were treated by Gaitianli tablet,with one treatment period of 30 days;The BMD,FBG,HbA1c,and the content of BGP,BALP,IGF-1 in the serum and PRO,Ca,P in urine were measured before and after treatment.Results：The BMD and BGP,IGF-1of serum increased significantly（P〈0.05 or P〈0.01）,and the FBG,HbA1c,BALP and the content PRO,Ca,P in urine decreased significantly（P〈0.05 or P〈0.01）in two group after treatment;The BMD and BALP of serum,and Ca,P in urine in treatment group is more improved than those of control group（P〈0.05）.Conclusion：Through regulating the correlation factor of bone metabolism and blood-fasting sugar of patients of type 2 diabetes with osteoporos,Tanggukang could decrease excrete of calcium and phosphours,and prevent the osteoporos.
出处
《中华中医药学刊》
CAS
2008年第12期2669-2671,共3页
Chinese Archives of Traditional Chinese Medicine
基金
河北省中医药管理局科学研究计划项目(2007203)
关键词
糖骨康
糖尿病骨质疏松
胰岛素样生长因子-1
钙磷代谢
Tanggukang
type 2 diabetes with osteoporos
insulin-like growth factor ，the metabolism of calcium and phosphours
