摘要
目的提高对肺癌皮肤转移的诊断水平。方法报告肺癌皮肤转移病例3例并综合1994～2008年国内文献,分析肺癌皮肤转移患者的性别和年龄分布、皮肤转移癌发生率、形态特征和发生部位、发生皮肤转移肺癌的病理类型、是否伴有其它部位的转移、皮肤转移癌与原发肺癌发现的先后关系及皮肤转移患者的治疗与预后。结果发生肺癌皮肤转移共193例,男150例(77.7%),女43例(22.3%);平均年龄60.5岁;皮肤转移发生率2.3%。皮肤转移为单发或多发结节、质硬,较固定;多见于胸壁、腹壁和肩背部。肺腺癌更易发生皮肤转移。多合并骨、肝、脑等脏器转移。大部分(69.3%)肺原发灶先于皮肤转移灶发现,小部分(12.8%)皮肤转移灶先于肺原发灶发现。部分患者接受了铂类为主的化疗方案,但疗效不佳;从发现皮肤转移灶至死亡的中位生存时间为4.1个月。结论肺癌皮肤转移发生率低,腺癌多见,常伴其它脏器转移,多在原发灶后发现,预示病期晚、预后不佳。
Objective To improve the level of diagnosis of skin metastasis of lung cancer.Methods Three cases in our hospital were reported and more cases were found in a search of domestic literature from 1994 to 2008.The clinic pathological features,treatment and prognosis characteristics of all these 193 cases were analyzed.Results Of the total 193 patients,150 cases（77.7%） were male and 43 cases（22.3%） were female.The average age was 60.5 years.The incidence of skin metastasis was 2.3%.All the skin metastasis were solitary or multiple nodule,fixed,with hard consistency.The most common sites of skin metastasis were chest wall,abdominal wall,shoulder and back.Adenocarcinoma had high tendency to metastasize to skin.Most patients accompained with bone,liver or brain metastasis.Most lung cancer（69.3%） were found before skin metastasis.Some patients received platinum-including regimen with low efficacy.The average survival time from skin metastasis to death was 4.1 months.Conclusion The incidence of skin metastasis of lung cancer is low.Adenocarcinoma is more common.Skin metastasis often accompaines with other organs metastasis and is found after lung cancer,which indicates late stage and bad prognosis.
出处
《华中医学杂志》
2009年第2期57-59,共3页
Central China Medical Journal
基金
山东省2007年度优秀中青年科学家科研奖励基金(No.2007BS-03064)
山东省医药卫生科研基金(No.2007QZ013)
关键词
肺肿瘤
肿瘤转移
皮肤
Lung neoplasms
Neoplasm metastasis
Skin
