摘要
观察了葡萄糖酸锌（ＺＧ）对小鼠顺铂（ＣＤＤＰ）半数致死量和顺铂引起的谷胱甘肽（ＧＳＨ）含量变化的影响。结果表明：ＺＧ明显提高顺铂的半数致死量（１１．９３～１５．６５ｍｇ·ｋｇ－１）（Ｐ＜０．０５），同时ＺＧ还能增加给予ＣＤＤＰ的小鼠血中ＧＳＨ含量，降低血和肾组织中脂质过氧化物（ＬＰＯ）的含量，提示：ＺＧ对顺铂的毒性具有防护作用，其可能机制就是改善体内巯基化合物的代谢，抑制脂质过氧化反应。
The effects of zinc gluconate(ZG) on LD_50cisdiaminodichloroplatin(CDDP) and glutathione(GSH) changes induced by CDDP were investigated in mice.The results showed that ZG elevated significantly LD_50 dose of CDDP(from 11.93mg·kg^-1to 15.65mg·kg^-1.ZG also increased GSH level in blood and decreased lipid peroxide(LPO) contents in blood and renal tissue(P<0.05 or P<0.01).It suggested that ZG have a protective effect against toxicity of CDDp and its mechanism may be involved in improving sulfhydryl metabolism and inhibityin lipid peroxidation.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1998年第2期55-56,共2页
Chinese Journal of Hospital Pharmacy
关键词
顺铂
葡萄糖酸锌
谷胱甘肽
脂质过氧化
Cisdiaminodichloroplatin, Zinc Gluconate,glutathione,Lipid peroxide
