摘要
【目的】探讨对ST段抬高的心肌梗塞(ST-elevation myocardial infarction,STEMI)患者进行溶栓治疗,应用不同起始剂量阿司匹林后的影响。【方法】我们选择了227例STEMI患者作为研究对象。我们比较了应用150 mg和300 mg阿司匹林后,24 h、7 d和30 d死亡率,和住院期间出现中-重度出血的发生率。【结果】113名患者接受首剂300 mg阿司匹林治疗,114名患者接受首剂150 mg阿司匹林治疗。300 mg组和150 mg组的24 h死亡率是3.54%vs3.51%。而7 d和30 d的死亡率分别是5.31%vs4.39%和7.08%vs6.14%(P>0.05)。300 mg组住院期间出现中-重度出血发生率是12.4%,而150 mg组是8.8%(P<0.05)。【结论】在STEMI治疗中首剂应用150 mg与300 mg阿司匹林效果相同,但安全系数前者大于后者。
[ Objective] To investigate the effect of different initial aspirin dose in ST-elevation myocardial infarction patients treated with fibrinolytic therapy. [Methods] A total of 227 ST-elevation myocardial infarction patients were selected for the study. Initial aspirin dose of 150 mg versus 300 mg was selected and 24-hour, 7-day and 30-day mortality, as well as rates of inhospital moderate/severe bleeding were cempared. [ Results] 113 patients received an initial aspirin dose of 300 mg, and 114 patients received 150 mg. The 24-hour mortality rates were 3.54% and 3.51% for those receiving an initial aspirin dose of 300 mg and 150 mg. Mortality rates at 7 and 30 days were 5.31% and 4.39% and 7.08% and 6.14% among patients receiving 300 mg and 150 mg aspirin. In-hospital moderate/severe bleeding occurred in 12.4% of those treated with 300 nag and 8.8% among those receiving 150 mg（ P 〈 0.05） . [ Conclusions] The initial dose of 150 mg aspirin may be as effective as and perhaps more safe than 300 mg for the acute treatment of ST-elevation myocardial infarction.
出处
《武警医学院学报》
CAS
2009年第2期125-126,129,共3页
Acta Academiae Medicinae CPAPF
关键词
阿司匹林
死亡率
出血
心肌梗塞
Aspirin
Mortality
Bleeding
Myocardial infarction
