摘要
目的本研究旨在通过检测卵巢癌组织中BRCA1、p53及Ki67蛋白表达情况及其相关性；了解BRCA1、p53及Ki67的表达与患者生存时间之间的关系。方法选取50例2003年卵巢上皮性癌根治术标本，对照组为10例正常卵巢组织标本；运用PV-9000二步免疫组化法检测BRCA1、p53及Ki67蛋白的表达，以及检测其与患者生存率的关系。结果BRCA1蛋自在卵巢癌组织中表达明显增多（阳性率为88．0％，P〈0．05）；BRCA1、p53及Ki67蛋白表达与患者年龄无关（P〉0．05）；BRCA1、p53及Ki67蛋白之间没有明显相关性（P〉0．05）；BRCA1、p53及Ki67蛋白表达与患者预后没有明显相关性（P〉0．05）。结论BRCA1蛋白在卵巢癌组织的表达量明显高于在正常卵巢组织中；BRCA1、p53、Ki67蛋白是否与患者的预后有关尚有待进一步深入研究。
Objectives To study the expression of protein BRCA1, p53 and Ki67 in epithelial ovarian cancer;To analyze the relationship between their expressions and prognosis. Methods An immunohistochemistry was performed on samples from 50 epithelial ovarian cancer. Results The expression of protein BRCA1 in ovarian cancer is much higher than that in the normal tissues （ expression rate 88.0% , P 〈 0.05 ） ; The expression of protein BRCA1, p53 and Ki67 are not correlated with each other（P 〉 0.05 ） ; The expression of protein BRCA1, p53 and Ki67 are not associated with ages （P 〉 0.05 ） ;The Kaplan Meier survival analysis shows that the survivals among the three proteins have no significance （ P 〉 0.05 ）. Conclusion Overexpression of BRCA1 is much more significant for than ovarian cancer that of normal ovarian tissues. BRCA1, p.53 and Ki67 might be used to predict the prognosis of ovarian cancer.
出处
《实用肿瘤学杂志》
CAS
2009年第2期134-138,共5页
Practical Oncology Journal
