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Synthesis and characterization of a novel amphiphilic biodegradable β-cyclodextrin/poly(γ-benzyl L-glutamate) copolymer

Synthesis and characterization of a novel amphiphilic biodegradable β-cyclodextrin/poly(γ-benzyl L-glutamate) copolymer
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摘要 β-Cyclodextrin/poly(γ-benzyl L-glutamate) (β-CD-PBLG) copolymers were synthesized by ring-opening polymerization of N- carboxy-γ-benzyl L-glutamate anhydride (BLG-NCA) in N,N-dimethylformamide (DMF) initiated by mono-amino-β-cyclodextrin(H2N-β-CD). The structures of the copolymers were confirmed by IR, ^1H NMR and GPC. The fluorescence technique was used to determine the critical micelle concentrations (CMC) of copolymer micell solution, the diameter and the distribution of micelles were characterized by DLS. The results showed that BLG-NCA could be initiated by H2N-β-CD to produce copolymer. The nanomicells were formed by these copolymers in water. β-Cyclodextrin/poly(γ-benzyl L-glutamate) (β-CD-PBLG) copolymers were synthesized by ring-opening polymerization of N- carboxy-γ-benzyl L-glutamate anhydride (BLG-NCA) in N,N-dimethylformamide (DMF) initiated by mono-amino-β-cyclodextrin(H2N-β-CD). The structures of the copolymers were confirmed by IR, ^1H NMR and GPC. The fluorescence technique was used to determine the critical micelle concentrations (CMC) of copolymer micell solution, the diameter and the distribution of micelles were characterized by DLS. The results showed that BLG-NCA could be initiated by H2N-β-CD to produce copolymer. The nanomicells were formed by these copolymers in water.
出处 《Chinese Chemical Letters》 SCIE CAS CSCD 2009年第3期362-365,共4页 中国化学快报(英文版)
基金 support of the Natural Science Foundation for Education Department of Liaoning Province of China(No.2007T051).
关键词 Β-CYCLODEXTRIN Poly(γ-benzyl-L-glutamate) Amphiphilic biodegradable copolymers Critical micelle concentration β-Cyclodextrin Poly(γ-benzyl-L-glutamate) Amphiphilic biodegradable copolymers Critical micelle concentration
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