摘要
目的:改进酒石酸托特罗定的合成工艺。方法:以对甲酚和肉桂酸为起始原料,经脱水、环合、水解、还原、酯化、胺化及拆分等反应制备标题化合物。结果:目标化合物的总收率为20%,结构经熔点、比旋光度、IR1、H-NMR确证。结论:此方法成本低廉,工艺安全简便,利于工业化生产。
Objective ： To study the synthesis of tolteridone hydrobromide. Methods ： Title synthesized from p-cresol and cinammic acid by dehydration, cyclization, hydrolysis, reduction, amidation and resolution. Results：The chemical structure of the product was identified by melting rotation, IR and ^1H-NMR. The yield was 20%. Conclusion ：This synthetic technique is simple and in industrial scale.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2009年第8期741-743,共3页
Chinese Journal of New Drugs
基金
黑龙江省教育厅科技项目(11521293)
关键词
托特罗定
合成
工艺改进
toheridone
synthesis
process improvement compound was sulfonylation, point, specific safe to produce
