摘要
目的探讨HBV基因型B、C与肝癌临床病理方面的关联性。方法对58名手术切除肝癌病人的血清样本进行基因型检测。结果HBV基因型B、C的感染率分别为31％（18／58）、69％（40／58），基因型B病人肝硬化的发病率低于基因型C（33％US70％，P=0．01）。基因型B、C多发肿瘤的发病率为28％、7．5％（P=0．04），伴有血管侵犯的发病率为33％、10％（P=0．03）。结论HBV基因型B相关性肝癌与HBV基因型C相关性肝癌相比，肝硬化发生率低，多发肿瘤及血管侵犯发病率高，造成了肝癌病人的复发及预后的差异性。
Objective To investigate whether HBV genotypes B and C influence the clinicopathological features of patients with resectahle HCC. Methods Stored serum samples from 58 patients with resectable HBV-related HCC were tested for HBV genotypes by a molecular method. Results Of the 193 patients undergoing resection of HCC, 18 （31%） and 40 （69%） were infected with genotypes B and C, respectively. Compared with genotype C patients, genotype B patients were less likely to be associated with liver cirrhosis （33% vs 70%, P= 0. 01）. Pathologically, genotype B patient showed a higher rate of mutiple tumor （28% vs 7.5%, P=0.04） and more vascular invasion （33% vs 10%, P= 0.03） than genmype C patients. Conclusion Genotype B-related HCC is less associated with liver cirrhosis and has a higher frequency of multiple tumour as well as more vascular invision than genotype Crelated HCC. These characteristics may contribute to the recurrence patterns and prognosis of HBV-related HCC in patients with genotype B or C infection.
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2009年第4期251-253,共3页
Chinese Journal of Hepatobiliary Surgery
关键词
癌
肝细胞
基因型
肝炎病毒
乙型
手术切除
Carcinoma hepatocellular
Genotype
Hepatitis B virus
Surgical resection
