摘要
目的探讨基质细胞衍生因子-1(SDF-1)治疗股骨头坏死的机制和疗效。方法选用日本大耳白兔30只,制成激素性股骨头坏死模型后,随机分为3组。A组为对照组;B组为髓心减压+生理盐水治疗组;C组为髓心减压+SDF-1治疗组。各组动物均于治疗后8周处死,处死后分别进行股骨头骨密度测定及组织病理观察。结果SDF-1治疗后8周,骨密度明显增高,病理组织学表现血管数目增多,空骨陷窝减少。SDF-1治疗后显示股骨头修复效果明显。结论髓芯减压SDF-1移植治疗股骨头缺血性坏死效果明显,具有较广的临床应用前景。
Objective To discuss the therapeutic mechanism and efficacy of stromal cell-derived factor-1 （SDF-1） in the treatment of femoral head necrosis. Methods Experimental models of hydrocortisone- induced femoral head necrosis were established in 30 Japanese rabbits, which were randomly and equally divided into three groups. Group A was regarded as control group, group B received marrow core decompression and saline injection treatment and group C underwent marrow core decompression and SDF-1 transplantation. Eight weeks after the procedure all the survival rabbits （n = 27） were sacrificed, and the specimens were sent for the measuring of bone mineral density and for histopathologic examination. Results Eight weeks after the treatment, the bone mineral density of rabbits in group C was significantly increased. Pathologically, in SDF-1 treated rabbits the amounts of the blood vessels and osteoblast cells were obviously increased while the empty bone lacunae were markedly decreased. Conclusion Transplantation of stromal cell-derived factor-1 together with marrow core decompression is very effective for the treatment of femoral head necrosis and this technique has showed a vast and bright prospect in clinical practice.
出处
《介入放射学杂志》
CSCD
北大核心
2009年第4期294-296,共3页
Journal of Interventional Radiology
基金
黑龙江省科学自然基金会(D200560)
关键词
股骨头坏死
缺血性
基质细胞衍生因子-1
髓芯减压
femoral head necrosis, avascular
stromal cell-derived factor-1
marrow core decompression
