摘要
目的:探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者手术前后血脂和空腹血糖(FBG)的变化,并分析手术前后患者BMI、睡眠呼吸暂停低通气指数(AHI)、最低血氧饱和度(LSpO2)的变化对血脂、FBG的影响。方法:31例重度OSAHS患者行Z形腭咽成形术(ZPP)或ZPP联合颏舌肌前移舌骨悬吊术(GAHM),测定患者手术前后血液总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、FBG等各项指标,并进行统计学分析。结果:①术前HDL与BMI及AHI呈负相关,而与LSpO2无关;②术后BMI、AHI、LS-pO2、HDL、FBG均有改善;③HDL的变化与BMI、AHI的变化均存在相关,且HDL与BMI存在线性相关(r=-0.36)。结论:ZPP或ZPP联合GAHM可以改善OSAHS患者的AHI、LSpO2、BMI,同时对FBG、血脂有改善作用;减轻体重以及纠正睡眠呼吸紊乱在改善OSAHS患者的糖脂代谢异常方面有着重要意义。
Objective：To compare the levels of the fasting blood glucose（FBG） and blood fat of the patients with obstructive sleep apnea hypopnea syndrome（OSAHS）before and after surgery, meanwhile to analyze the influence on blood glucose and blood fat after the changes of body mass index（BMI）, apnea hypopnea index（AHI） and lowest oxygen saturation（LSpO2 ）. Method： Thirty-one patients with severe OSAHS were performed Z-palatoplasty（ZPP） or ZPP combined with genioglossus advancement with hyoid suspension（GAHM）. Cholesterol（TC）, triglyceride（TG）, high density lipoprotein （HDL）, low density lipoprotein（LDL） and FBG were detected before and after surgery. Result：Preoperative HDL was negatively related to BMI and AHI, but not LSpO2. After surgery the BMI, AHI, LSpO2 , HDL and FBG were all improved. The change of HDL had correlation with the changes of BMI and AHI, and there was linear correlation with HDL and BMI（r=-0.36）. Conclusion：The surgery of ZPP and ZPP combined with GAHM can improve the AHI, LSpO2 ,BMI, the FBG and blood fat of the patients with OSAHS. Lose weight and rectifying steep disordered breathing were important to improve glyeolipid metabolism disorder of the patients with OSAHS.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2009年第9期391-393,共3页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
