摘要
目的探讨卡培他滨单药或联合方案治疗晚期胃癌的疗效及安全性。方法104例晚期胃癌患者接受如下方案治疗：（1）卡培他滨单药组：卡培他滨1000mg／m^2，口服，20t／,a，第1～14天，21d为1个周期。（2）卡培他滨＋紫杉类组：卡培他滨1000mg／m^2，口服，2次／d，第1—14天；紫杉醇175mg／m。，静脉滴注，第1天（或80—90mg／m^2，静脉滴注，第1、8天）；或多西紫杉醇65—75mg／m^2，静脉滴注，第1天；21d为1个周期；（3）卡培他滨＋铂类组：卡培他滨1000mg／m^2，口服，2次／d。第1—14天；顺铂15～20mg／m^2，避光静脉滴注2h，第1-5天；或奥沙利铂130mg／m^2，静脉滴注2h，第1天；21d为1个周期。中位治疗3个周期。结果104例患者的总客观有效率为20．6％，中位生存时间为8．5个月，中位疾病进展时间为5．2个月。在可评价疗效的患者中，一线治疗的客观有效率为40。0％，疾病控制率为76．7％。卡培他滨＋紫杉类化疗组的总中位生存期为10．9个月，一线治疗的中位生存期为12．8个月。卡培他滨单药组的不良反应发生率最低。结论以卡培他滨为基础的治疗方案疗效尚可，患者耐受性好，单药治疗适用于KPS评分〈80分的患者，联合紫杉类化疗组的患者生存时间略长，但尚需进一步验证。
Objective To evaluate the toxicity and efficacy of capecitabine-based chemotherapy in the treatment of advanced gastric cancer. Methods 104 patients with advanced gastric cancers were treated with capecitabine-based chemotherapy regimens from Sept. 2001 to May 2007. Group 1 was treated by capecitabine 1000 mg/m^2 orally twice daily on Dl-14, repeated every 3 weeks;group 2 by capecitabine as that of group 1, and combined with paclitaxel 175 mg/m2 intravenous infusion on D1 （ or 80-90 mg/m2 on D1, D8 ） ,or docetaxel 65-75 mg/m^2 on D1 ,repeated every 3 weeks; group 3 by capecitabine as that of group 1, combined with cisplatin 15-20 mg/m2 intravenous infusion for 2 h on D1-5 ,or oxaliplatin 130 mg/m^2 for 2 h on D1, repeated every 3 weeks. The median cycles of treatment were 3 cycles. Results The overall response rate was 20.6%. The median overall survival and the median time to progression were 8.5 months and 5.2 months, respectively. For the first-line chemotherapy, ORR was 40.0% , disease control rate was 76.7%;the median overall survival in all patients and in the patients with first-line chemotherapy of capecitabine plus paclitaxel were 10. 9 months and 12. 8 months, respectively. The adverse events in capecitabine alone group were the least among all the groups. Conclusion The capecitabine-based chemotherapy was effective and tolerable. The patients with KPS 〈 80 may choose capecitabine alone for the chemotherapy. The regimen of capecitabine combined with paclitaxel was more effective than other regimens. However, further investigation to improve it is still required.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2009年第4期312-315,共4页
Chinese Journal of Oncology
关键词
胃肿瘤
药物疗法
卡培他滨
Stomach neoplasms
Drug therapy
Capecitabine
