摘要
目的探讨氟比洛芬复合丙泊酚静脉麻醉应用于人工流产术的麻醉效果及最佳剂量。方法年龄19～42岁接受人工流产术者100例,随机分为4组(n=25):氟比洛芬25mg复合丙泊酚组(氟25mg组)、氟比洛芬50mg复合丙泊酚组(氟50mg组)、氟比洛芬75mg复合丙泊酚组(氟75mg组)、氟比洛芬空白乳剂复合丙泊酚组(对照组)。各组分别于注射丙泊酚前5min注射氟比洛芬或氟比洛芬空白乳剂。结果4组间麻醉诱导时间、手术时间无显著差异(P>0.05)。氟比洛芬各组苏醒时间、丙泊酚用量、术后宫缩痛评分及丙泊酚注射痛评分均小于对照组,氟50mg组、氟75mg组麻醉效果优于对照组(P<0.05)。术中4组血压、心率变化无明显差异,氟50mg组和氟75mg组体动发生率分别为28%(7/25)和20%(5/25),低于对照组60%(15/25),差异显著(P<0.05)。结论氟比洛芬50mg、75mg复合丙泊酚静脉麻醉应用于人工流产术麻醉效果好,苏醒质量高。
AIM To investigate the effect and optimal dose of flurbiprofen combined with propofol for induced abortion anesthesia. METHODS One hundred induced abortion patients aged 19 - 42 years, were randomly divided into 4 groups （n = 25 for each） ： flurbiprofen 25 mg combined with propofol （group F25）, flurbiprofen 50 mg combined with propofol （group F50）, flurbiprofen 75 mg combined with propofol （group F75）, blank emulsion combined with propofol （control group）. All patients were taken intravenous infusion of flurbiprofen in the former 3 groups and blank emulsion in the control group 5 min before injection of propofol. RESULTS Induction time and operation time of four groups showed no significant differences （P 〉 0.05）. Conscious recovery time, propofol dosage, post-operative hypogastric pain of VAS score and VRS pain score of propofol injection in all flurbiprofen groups were lesser than those of the control group （P 〈 0.05）. Anesthesia effects of group F50 and group F75 were more satisfactory than that of the control group （P 〈 0.05）. Changes of BP and HR in the four groups had no significant difference （P 〉 0.05）. Incidences of restlessness of the group F50 and F75 were 28% （7/25） and 20% （5/25）, lower than 60% （15/25） of the control group （P 〈 0.05）. CONCLUSION Flurbiprofen 50 mg or 75 mg combined with propofol for abortion anesthesia is not only satisfactory, but also with high quality of conscious recovery.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2009年第4期273-276,共4页
Chinese Journal of New Drugs and Clinical Remedies
关键词
氟比洛芬
丙泊酚
流产
人工
flurbiprofen
propofol
abortion, induced
