摘要
目的探讨脑梗死患者颈动脉粥样硬化与血清基质金属蛋白酶-9(MMP-9)水平的关系。方法应用彩色Doppler超声诊断仪检测颈动脉内膜中层厚度(IMT),以及有无斑块形成及斑块形态。应用双抗体夹心酶联免疫吸附法(ELISA)检测100例脑梗死患者的血清MMP-9水平,并进行相关分析。结果不稳定斑块组空腹血清MMP-9浓度为(549.93±153.12)ng/ml,高于稳定斑块组和无斑块组的(281.45±120.34)ng/ml和(87.36±23.62)ng/ml,差异具有统计学意义(P<0.01)。结论血清MMP-9水平的升高,可成为颈动脉粥样硬化斑块易损性的独立预测因素。血清MMP-9水平增高与颈动脉粥样硬化斑块不稳定性密切相关。
Objective To investigate the relationship between serum MMP-9 levels and carotid atherosclerosis in patients with cerebral infarction. Methods All carotid arteries of the patients were examined with color Doppler ultrasound and intima-media thickness （IMT） and the shape of plaques were measured. The levels of serum MMP-9 in Patients with Cerebral infarction （n = 100 ） were measured respectively. Results The levels of serum MMP-9 in unstable-plaque group was（549. 93 ± 153.12）ng/ml, It was significantly higher than（281.45 ± 120. 34） ng/ml and （ 87.36 ± 23.62 ） ng/ml in the stable-plaque group and the non-plaque group （P 〈 0. 01 ） ,respectively. Conclusions The elevation of the serum MMP-9 levels may be the independently prediction factors for the wearing of the carotid atherosclerotic plaques. It is closely associated with the occurrence and development of ischemic stroke.
出处
《中华临床医师杂志（电子版）》
CAS
2009年第4期43-45,共3页
Chinese Journal of Clinicians(Electronic Edition)
基金
滕州市科技发展基金资助项目(2008037)
关键词
脑梗死
颈动脉
动脉粥样硬化
基质金属蛋白酶9
Brain infarction
Carotid arteries
Atherosclerosis
Matrix metalloproteinases 9
