摘要
1例17岁男性慢性粒细胞白血病患者服用伊马替尼400mg,2次/d,治疗约4个月无效,后改用达沙替尼70mg,2次/d。约1个半月后,患者开始出现发热(39.2℃),之后出现全身肌肉、骨骼和关节疼痛。给予吲哚美辛栓50mg,3次/d塞肛和地塞米松2.5mg静脉滴注,患者疼痛减轻。因病情需要,患者继续服达沙替尼,再次出现疼痛,给予吲哚美辛栓塞肛治疗。
A 17-year-old boy with chronic granulocytic leukemia was treated with imatinib 400 mg twice daily for about 4 months, but this had no effect. Later, imatinib was changed to dasatinib 70 mg twice daily. About one morth and a half later, the patient initially presented with body temperature of 39.2℃, followed by generalized myalgia, ostalgia, and arthralgia. After treatment with I rectal indometacin 50 mg suppository thrice daily and an IV infusion of dexamethasone 2.5 mg, his pains lessened. Dasatinib was continued for the clinical needs of the patient. His pains reappeared, and rectal indometaein suppositories were given.
出处
《药物不良反应杂志》
2009年第2期133-134,共2页
Adverse Drug Reactions Journal
关键词
达沙替尼
肌痛
骨痛
关节痛
不良反应
dasatinib
myalgia
ostalgia
arthralgia
adverse reactions
