摘要
目的:探讨膀胱灌注辣椒辣素类似物(RTX)治疗女性膀胱过度活动症(OAB)的临床效果。方法:34例OAB患者随机分为实验组与对照组,实验组19例用0.5%利多卡因溶液40mL从导尿管注入膀胱,保留3min后全部排出,予以膀胱灌注辣椒辣素类似物(RTX)治疗,对照组15例用1:5000呋喃西林(安慰剂)替代RTX,方法同实验组。观察两组用药前、用药后1个月、3个月、6个月的临床症状(每日排尿次数、尿急程度)。结果:治疗前与治疗后1个月、3个月、6个月的临床症状比较,实验组差异有显著意义(P<0.01)。10/19例(52.6%)有轻度尿道刺激症状或膀胱区不适,均可耐受。对照组无差异(P<0.05)。结论:RTX单剂量膀胱灌注能安全有效地改善女性OAB临床症状。
Objective To explore the clinical outcomes of intravesical instillation resiniferatoxin （RTX） for the treatment of patients with overactive bladder in female. Methods 34 cases with OAB were randomly divided into test （19 cases） and control （15 cases） groups. The patients in test group were treated by intravesical instillation with 40 mL of 0.5% lidocain retained within the bladder for 3 minutes at first and with 100 mL of 100 nmol/L RTX retained within the bladder for 30 minutes late. The patients in control group were treated by the same method, however, the furacilin solution （placebo） at a dilution 1：5000 was used instead of 100 nmol/L RTX.The efficacy （daily voiding frequency, urgent uresis） of the 2 groups were evaluated before, 1 month, 3 months and 6 months after treatment. Results Before treatment in test group compared with test group at 1 month, 3 months and 6 months after treatment was significant （ P 〈 0.01）, and control group was not significant （P 〉 0.05）. 14/19 patients （52.6%）had slightly stimulating symptom in the urethra or bladder, and were otherwise generally well tolerated. Conclusion Single administration of RTX is safe and effective in patients with OAB in female.
出处
《深圳中西医结合杂志》
2009年第2期101-103,共3页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
基金
深圳市科技计划资助项目(200803041)
