摘要
目的:在分子水平评价化合物L20051117和AMMS607对甲型流感病毒和乙型流感病毒神经氨酸酶(NA)活性的抑制作用。方法:通过测定流感病毒NA的荧光密度来确定化合物对流感病毒NA的抑制活性。结果:L20051117对NA的抑制活性高于AMMS607,且两者对甲型流感病毒NA抑制作用均略优于对乙型流感病毒NA的抑制作用。结论:通过体外测定L20051117和AMMS607对流感病毒NA的抑制活性,初步确定L20051117和AMMS607对流感病毒有一定抑制作用,且L20051117的作用效果优于AMMS607。
Objective：To determine the inhibitory effect of compounds L20051117 and AMMS607 on influenza virus neuraminidase at molecular level. Methods：The anti-influenza virus neuraminidase activity of L20051117 and AMMS607 was examined by the fluorimetric assay. Results ：The inhibitory effect of L20051117 on influenza virus neuraminidase was higher than that of AMMS607, the inhibition of influenza A virus neuraminidase by L20051117 and AMMS607 was higher than that of influenza B virus neuraminidase. Conclusion： L20051117 is a potent inhibitor of the neuraminidase activity of both influenza A and B virus. Its in vitro activity is higher than AMMS607.
出处
《军事医学科学院院刊》
CSCD
北大核心
2009年第2期135-136,共2页
Bulletin of the Academy of Military Medical Sciences
