摘要
目的探讨多发伤患者外周血血清降钙素原(PCT)和C反应蛋白(CRP)与多器官功能障碍综合征(MODS)的关系及临床意义。方法将76例多发伤患者按照治疗过程中有无MODS发生将患者分为非MODS组和MODS组,检测两组患者外周血血清PCT、CRP含量。结果对照组PCT和CRP含量在各时相点基本无变化。两组患者的PCT含量的最高值均出现在伤后第1天,随着时间的延长逐渐下降。非MODS组的外周血CRP含量随着时间的延长,呈下降趋势。而MODS组的外周血CRP含量的最高值出现在伤后第2天,而后呈现快速下降。两组在伤后各天的CRP变化与对照组比较都存在显著性差异(P<0.05)。通过对比CRP作为MODS诊断的指标,CRP效率高于PCT。结论创伤后急性期CRP水平的升高程度与继发性MODS的发生相关性高。测定严重多发伤外周血血清CRP含量对预测继发性MODS的发生具有一定价值。PCT可为诊断MODS补充信息。
Objective To investigate the relation of the peripheral blood procalcitonin （ PCT ）, C-reactive protein（CRP） and multiple organ dysfunction syndrome （MODS） for patients with multiple trauma. Methods A total of 76 patients with multiple trauma were divided into non-MODS group and MODS group. Peripheral blood PCT and CRP concentration were detected. Results The PCT and CRP level of the control group changed a little during the whole observation. The highest concentration of PCT value in the two groups was observed on the first day after injury, and then declined gradually. Peripheral blood concentration of CRP in non-MODS group had a downward trend. The highest concentration of peripheral blood CRP appeared on the second day after injury and then declined in MODS group. CRP concentrations were significantly different compared with that in the control group. By taking CRP as an indicator of the diagnosis of MODS, CRP was more efficient than PCT. Conclusion The results suggest that the CRP level is relevant to the occurence of secondary MODS after trauma. The observation of peripheral serum CRP concentration can predict the occurrence of secondary MODS.
出处
《创伤外科杂志》
2009年第3期253-255,共3页
Journal of Traumatic Surgery
