摘要
目的:对比与分析干预前后围手术期预防性应用抗菌药物状况,促进临床科学、合理用药。方法:将本院2006年11月至2008年7月入选住院手术病例分为对照组、干预2组,实施围手术期预防应用抗菌药物干预与对比。随机抽取Ⅰ、Ⅱ类切口10个[Ⅰ-Ⅱ(7∶3)]单病种手术干预前后出院手术病历每组72份,共计144份[Ⅰ-Ⅱ(7∶2)],对应用的抗菌药物品种、用程、用药频度、联合用药、药物不良反应、标本送检率等方面进行了统计、对比与分析。结果:围手术期人均抗菌药物费用由1238.3元下降为340.87元(P<0.01);住院期间人均药品费用由2998.17元下降为1145.25元(P<0.01);人均住院总费用由6867.84元下降为4532.78元(P<0.01);人均抗菌药物应用天数由原来7.61d缩短至2.86d(P<0.01);人均住院天数由原来11.43d缩短至7.14d(P<0.01);二联、三联用抗菌药物百分率分别由原来77.78%,6.94%分别降至31.94%,4.17%;药敏送检率由原来27.12%提高至81.82%;2组患者性别比例差异无显著性;2组患者年龄差异存在显著性(P<0.05),干预组住院患者的平均年龄低于对照组住院患者的平均年龄;预防应用抗菌药物的合理率(合理+基本合理)由干预前1.38%上升至95.83%,合理率有显著提高。结论:恰当的干预是有效、可行的,对围手术期安全、有效、合理、经济地预防应用抗菌药物起到了积极的促进作用。
OBJECTIVE To compare and analye,on the status of pre and post intervention of usage of prophylactic antibacterial drugs on perioperative period, and to promote the development of scientific and rational clinical usage of antibacterial drugs, METHODS The cases selected on inpatient surgical cases were divided to intervention group and non-intervention group during from Nov. 2006 to July. 2008 in our hospital , and intervention on usage of prophylactic antibacterial drugs during perioperative period was carried out and compared at the same period . 144 （ Ⅰ ： Ⅱ , 7 ： 2） cases of dischaged patients with 72 cases by per group in clean incision and clean-defiled incision on ten monophy （ Ⅰ ： Ⅱ ,7 ： 3）were randomly sampled , and maked statistics, analysis and evaluation in respect of antibacterial drug variety , course , frequency , combined use , costs , drug adverse reaction and examining rate of the samples. RESULTS The average drug costs during staying in our hospital was decreased from 2998. 17 yuan to 1145.25 yuan（P〈0. 01） and the average antibacterial drug costs by person during perioperative period was decreased from 1238. 3 yuan to 340. 87 yuan （P〈0. 01） and the total costs was decreased from 6867. 84 yuan to 4532. 78 yuan （P 〈0. 01） pre and post intervention;The average antibacterial drug couse was decreased from 7.61 days to 2. 86 days （P〈0. 01 ） and the average hospitalization days was decreased from 11.43 days to 7.14 days （P〈0.01） ; The usage of two and three combined antibacterial drugs were decreased from 77.78% and 6.94% to 31.94% and 4. 17% respectiveely ; Examing rate of the samples was increased from 27.12% to 8l. 82% ; The ages of inpatients from the two groups were compared and there was a great difference （P〈0. 05）, and the average age of inpatients from intervention group was below the average age of inpatients from non-intervention group. The rational rate of prophylactic usage of antibaeteria drug is increased from 1.38% to 95.83% pre and post intervention , and there was a remarkable improvement on rationality in intervention group. CONCLUSION It is practicable and effective to rational implemention in intervention group, and it plays an active role on promoting prophylactic usage of safely , rationally, effectively and economic antibacterial drugs on perioperative period.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2009年第9期741-746,共6页
Chinese Journal of Hospital Pharmacy
基金
上海市黄浦区卫生系统临床研究基金项目(编号:HWY-06148)
关键词
围手术期
抗菌药物
预防用药
干预前后对比
Perioperative period
Antibacterial drug
Rational drug usage
Intervention and comparison
