摘要
目的研究小肠脂肪酸结合蛋白(IFABP)基因exon II54位点基因多态性与新生儿低出生体质量的关联。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法,对86例低出生体质量儿和96例健康新生儿的IFABP基因多态性进行了检测,比较两组的基因型分布频率。结果IFABP基因型A54T频率分布为:AA、TT和AT基因型在疾病组中分别为24.4%、5.8%、69.8%,在对照组中分别为20.8%、41.7%、37.5%,分布频率差异有统计学意义(P=0.000)。T等位基因频率分别为40.7%和60.4%(P=0.000)。结论IFABP A54T基因多态性可能是低出生体质量儿的遗传易感因素;携带IFABP基因突变型54Ala/Thr的个体易患新生儿低体质量。
Objective To investigate whether genetic polymorphism in the intestinal fatty acid binding protein （IFABP） gene is associated with low birth mass in neonates. Methods Polymerase chain reaction-restriction fragment length polymorphism was used to detect the polymorphism in 86 low birth mass neonates and 96 normal ones. Results The A54T site frequencies of AA, TT, AT genotypes of IFABP gene were 24. 4 %, 5.8 %, 69.8 % in disease group while those were 20.8%, 41.7%, 37.5% in normal controls, the differences were significantly seen in the distribution frequency between two groups （ P = 0. 000）. Conclusion The combination between genetic polymorphisms in the IFABP gene in neonates is significantly associated with neonatal low birth mass;the frequency of encoding 54Ala/Thr polymorphism in IFABP gene is related with low birth mass.
出处
《临床荟萃》
CAS
2009年第10期863-865,共3页
Clinical Focus
基金
国家自然科学基金资助项目(30571604)
关键词
婴儿
出生时低体重
基因频率
脂肪酸转运蛋白质类
聚合酶链反应
IFABP, polymorphisms infant, low birth weight
gene frequency
fatty acid transport proteins
polymerase chain reaction
