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右丙亚胺在女性乳腺癌术后辅助化疗中对心脏的保护作用 被引量：7

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摘要 目的观察右丙亚胺(Dexrazoxane,DEX)对早/中期女性乳腺癌患者术后表阿霉素(EPI)辅助化疗时的心脏保护作用。方法随机将来我院治疗的早/中期女性乳腺癌患者分为观察组和对照组,两组患者均采用EPI为主的术后辅助化疗方案,观察组在EPI为主的化疗方案基础上加用DEX(DEX∶EPI=10∶1),在第1次应用EPI时即给予DEX。采用心肌钙蛋白T(cTnt)和左心室射血分数(LVEF)监测治疗前、治疗第1和第3个周期、治疗完成时、完成后半年、1年和2年的心脏功能状态,同时观察治疗的非心脏毒性。结果两组患者在年龄、体重、ECOG评分和分期方面没有统计学差异(P>0.05)。EPI治疗第1个周期开始cTnt明显上升,到治疗结束时达到最高,直到治疗后2年仍然维持在较高水平;加用DEX组在治疗期间及治疗后cTnt水平都较低;而LVEF在两组的各个治疗阶段水平都没有统计学差异(P>0.05);两组的非心脏副反应没有差异。结论EPI从第1次应用时对心脏就产生了明显的毒性,加用DEX可以降低这种心脏毒性。
作者 徐晓华 续哲丽 徐前 王颜荣 张志军 吴美玲
机构地区 吉林大学中日联谊医院感染科 吉林大学中日联谊医院外科 天津市宁河县中医院儿科 吉林省肿瘤医院化疗科 江苏奥赛康海光应用化学研究所
出处 《中国老年学杂志》 CAS CSCD 北大核心 2009年第9期1120-1122,共3页 Chinese Journal of Gerontology
关键词 乳腺癌 辅助化疗 表阿霉素 右丙亚胺 心肌钙蛋白T 左心室射血分数
分类号 R737.9 [医药卫生—肿瘤]
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参考文献10

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同被引文献47

  • 1陈天佳,赵力.老年人心律失常的动态心电图特点及其临床意义[J].中国老年学杂志,2004,24(9):783-784. 被引量：10
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中国老年学杂志
2009年 第9期

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