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ApoE与阿尔茨海默病 被引量:2

Role of ApoE in Alzheimer's disease
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摘要 载脂蛋白E(ApoE)基因型是现在所知的散发型和迟发型阿尔茨海默症的最大的危险因子,它是中枢神经系统中主要的胆固醇运载体,同时又是极低密度脂蛋白(VLDL)的组成成分。ApoE对脑内胆固醇代谢异常和β-淀粉样蛋白沉积等阿尔茨海默症的典型特征有重要作用,对于ApoE在阿尔茨海默症中生化作用机制的研究对于我们对其发病机理的深入认识及治疗有重要意义。 The genotype for apolipoprotein E (ApoE) is the strongest known risk factor in sporadic or late onset Alzheimer's disease. ApoE is a major carrier of cholesterol in the central nervous system and an important component of very low density lipoproteins (VLDL). It plays critical roles in the disorder of cholesterol in the brain, the formation of β--amyloid plaque and other symptoms of Alzheimer's disease. It's very important to study ApoE biochemical mechanisms for deeply understanding the pathogenesis and treatment of Alzheimer's disease.
出处 《神经疾病与精神卫生》 2009年第2期93-95,共3页 Journal of Neuroscience and Mental Health
基金 国家自然基金项目(项目号30570553,30670414) 科技部973项目(2006CB500705)及大医学部基础学院创新人才项目资助
关键词 阿尔茨海默病 载脂蛋白E 脂类 Alzheimer's Disease ApoE Lipids
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参考文献26

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