摘要
目的：介绍干扰素治疗恶性肿瘤，特别是晚期实体瘤临床应用的新进展。方法：利用干扰素与抗肿瘤药物之间的生化调节作用治疗临床上常见且化疗和放疗效果不佳的晚期实体瘤。结果：干扰素治疗多种恶性肿瘤已取得较好的成绩，其中包括肾癌、黑色素瘤和多发性骨髓瘤等。除此之外，干扰素联合化疗和放疗对大肠癌、肺癌等晚期癌症的治疗也取得了一定的经验。结论：干扰素治疗晚期恶性肿瘤需与化疗合用，要注意长期、大剂量应用干扰素时出现的不良反应。
OBJECTIVE:To introduce the recent progress of interferon in treatment of malignant tumors,especially advanced solid cancers.METHODS:The biochemical modulation effects existed between IFN and anticancer drug,were used in treatment of advanced solid cancers which are not response to chemotherapy and radiotherapy.RESULTS:Good clinical results have been obtained by using this method in treatment of advanced cancer such as renal cell carcinoma,malanoma,multiple myelima and so on.In addition,some experience in treating colorectal cancer,lung cancer by IFN combined with chemotherapy and radiotherapy were also obtained.CONCLUSION:It is necessory to combine IFN with chemotherapy in treatment of advanced cancer.The side effects of IFN in high doses and long term use should take care of.
出处
《中国新药杂志》
CAS
CSCD
1998年第1期12-15,共4页
Chinese Journal of New Drugs
