摘要
应用全反式维甲酸（ＡＴＲＡ）治疗４５例急性早幼粒细胞白血病（ＡＰＬ），分析治疗中白细胞数量对ＡＴＲＡ治疗ＡＰＬ的影响。结果显示：３３例出现高白细胞症，发生率为７３．３％。其中ＷＢＣ＜２０×１０９／Ｌ者完全缓解率１００％。加用化疗可延长获ＣＲ时间；＞２０×１０９／Ｌ者完全缓解率随ＷＢＣ高峰值的升高而下降。提示粒细胞清除后给予小剂量ＡＴＲＡ、细胞毒药物及地塞米松联合治疗是治疗高白细胞症的一种有效措施。
45 patients with acute promyelocytic leukemia(APL) treated with all-trans retinoic acid(ATRA) were studied. The effects of white blood cell (WBC) counts of APL treated with ATRA were analysed during the therapy. The results showed that the 33 cases out of the 45 developed hyperleukocytosis (73.3%). All of the patients with WBC counts less than 20×109/L attained complete remission (CR), and the duration of CR could be prolonged by using ATRA in combination with the chemical therapy. The CR rate decreased with WBC counts increasing more than 20×109/L. Following the granulocytes apheresis, the therapy of combining low doses of ATRA with the cytotoxic drug and dexamethasone were effective in the treatment of hyperleukocytosis.
出处
《白血病》
1998年第1期16-18,共3页
