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柴芍六君子汤联合恩替卡韦治疗慢性乙型肝炎(肝郁脾虚证)30例临床观察 被引量:10

Effect of Chai Shao Liujunzi Decoction Combined with Entecavir for the Treatment of Chronic Hepatitis B:An Observation of 30 Cases
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摘要 【目的】观察柴芍六君子汤联合恩替卡韦治疗慢性乙型肝炎(肝郁脾虚证)的临床疗效。【方法】将60例患者随机分为2组。治疗组30例给予柴芍六君子汤联合恩替卡韦治疗,对照组30例单用恩替卡韦治疗。治疗3个月、6个月、1年后分别观察HBV-DNA定量及阴转率、谷丙转氨酶(ALT)复常率、核心抗原(HBeAg)血清转换率的变化以及临床症状改善情况。【结果】(1)2组在治疗3个月、6个月及1年后检测HBV-DNA的下降幅度及阴转率比较,差异均无显著性意义(P>0.05)。(2)治疗组治疗3个月后ALT复常率优于对照组(P<0.05),但在治疗6个月及1年后,2组ALT复常率比较差异均无显著性意义(P>0.05);治疗组在治疗1年后HBeAg血清转换率高于对照组(P<0.05)。(3)治疗组在改善胃纳差、睡眠欠佳、胁肋部疼痛、腹胀等方面,其总有效率优于对照组(P<0.05或P<0.01)。【结论】柴芍六君子汤联合恩替卡韦能够更有效地促进肝功能恢复,提高HBeAg的血清转换率,并能有效地改善患者各种临床症状。 Objective To observe the therapeutic effect of Chai Shao Liujunzi Decoction (CSLD) combined with entecavir for the treatment of chronic hepatitis B (CHB) patients with hepatitis B e antigen (HBeAg) positive which were differentiated as liver stagnation and spleen deficiency. Methods Sixty qualified patients were equally randomized into 2 groups: the control group received entecavir, and the treatment group received CSLD combined with entecavir. After treatment for 3 months, 6 months and one year, the DNA quantification of hepatitis B virus (HBV), normalization rate of alanine aminotransferase (ALT), and rate of HBeAg turning negative were observed. Results The decrease of HBV-DNA and the rate of HBV-DNA turning negative in the treatment group did not differ from those in the control group after treatment for 3 months, 6 months and one year (P 〉 0. 05).Normalization rate of ALT was higher in the treatment group than that in the control group ( P 〈 0. 05 ) after treatment for 3 months, but the difference of ALT normalization rate after treatment for 6 months and one year was insignificant between the two groups (P 〉 0.05 ). The rate of HBeAg turning negative in the treatment group after treatment for one year was higher than that in the control group ( P 〈 0. 05 ) ; and the total effective rate on relieving poor appetite, poor-quality sleep, pain in hypochondrium, and abdominal distention was higher in the treatment group than that in the control group ( P 〈 0.05 or P 〈 0. 01 ). Conclusion CSLD combined with entecavir is effective for promoting the recovery of hepatic function, increasing the rate of HBeAg turning negative, and relieving clinical symptoms of patients with chronic hepatitis B.
出处 《广州中医药大学学报》 CAS 2009年第3期218-220,224,共4页 Journal of Guangzhou University of Traditional Chinese Medicine
关键词 肝炎 乙型 慢性/中西医结合疗法 肝郁脾虚 柴芍六君子汤/治疗应用 HEPATITIS B, CHRONIC/TCM-WM therapy LIVER STAGNATION AND SPLEEN DEFICIENCY CHAI SHAO LIUJUNZI DECOCTION/therapeutic use
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