摘要
目的探讨危重病患者血清甲状腺激素水平的动态变化及临床意义。方法30例收入急诊重症监护室的危重患者,用放射免疫分析法分别测定第1、3、5、10d的甲状腺激素(T3、T4、rT3、TSH)水平,若患者10d内死亡,则测定其临终前的激素水平。结果危重病患者的甲状腺激素水平T3及T4水平低于对照组;rT3水平高于正常组;TSH值略高或正常;经过原发病治疗后,存活的危重患者血清甲状腺激素各项异常指标在缓解期均恢复正常水平,和急性期相比有显著性差异(p<0.01)。危重病组中死亡患者T3及T4水平明显低于存活患者(p<0.01),rT3则高于存活患者。结论甲状腺激素参与了危重患者的病理生理过程,监测危重患者血清甲状腺激素水平变化可作为反映病情严重程度及预后的一项指标。
Objective To investigate the clinical significance of changes of serum thyroid hormone（TH） in critical patients and the clinical significance of TH level as a predictor of prognosis in these patients. Methods In 30 critical patients who received intensive care for more than 5d,serum thyroid hormone were measured by radioimmunoassay on d 1,3,5,10 or on the day of death. Resuits Compared with non - critical patients ,the serum T3 ,T41evels in critical patients were dramatically lowered（p 〈0.01 ） ,the serum rT3 was higher（p 〈0.01 ） ,and TSH level showed no difference（p 〉0.05 ）. Among critical patients the serum T3 and T4 levels in death cases were significantly lower than those in survivors （p 〈 0.01 ）. After being treated for primary conditions, those who survived showed recovery of TH levels during convalescence in contrast to acute stage（p 〈 0.01 ）. Conclusion Changes in thyroid hormones level,comparing with non -critical patients,may be helpful for evaluating the outcomes and prognosis in critical patient.
出处
《现代医院》
2009年第5期72-73,共2页
Modern Hospitals
关键词
危重病
甲状腺激素
预后
Critical patients, Thyroid hormone, Prognosis
