摘要
目的探讨胃癌组织中Leptin和VEGF蛋白的表达及病理学意义。方法采用免疫组化SP法检测20例胃炎组织及50例不同分化程度胃癌组织中Leptin、VEGF的表达。结果(1)胃癌中Leptin的阳性表达明显高于胃炎组织(P<0.01),并与胃癌的分化分型有关,与胃癌的淋巴结转移有关(P<0.05)。(2)胃癌中VEGF的阳性表达显著高于胃炎组织(P<0.01),并与胃癌的分化分型都有关,且与胃癌的淋巴结转移有关(P<0.05)。(3)Leptin与VEGF在胃癌中的表达呈正相关(r=0.635,P<0.01)。结论Leptin和VEGF与胃癌的浸润,转移有关,Leptin可能因协同VEGF或通过上调VEGF的表达而在胃癌的浸润、转移中发挥了一定的作用。
Aim To investigate the pathological significance of the expression of leptin and VEGF in human gastric cancer. Method Leptin and VEGF were detected by immunohistochemistry streptavidin - peroxidase method （ S - P method） in 20 gastritis and 50 gastric cancer. Results First, leptin positive expression in gastric carcinoma is higher than that in gastritis （ P 〈 0.01 ）, and leptin positive expression is correlated with the lymph node metastasis of gastric cancer, pathological type and classification degree （P 〈 0. 05 ）. Second, VEGF positive expression in gastric cancer is more than that in gastritis （ P 〈 0.01 ） , and VEGF positive expression is correlated with pathological type, classification degree and lymph node metastasis （ P 〈 0.05 ）. Third, the expression of leptin in GC is positively correlated with that of VEGF（ r = 0. 635, P 〈 0. 01 ）. Conclusion Leptin and VEGF eountribute to the invasion and metastasis in gastric carcinoma. Leptin might be reponsible for the enhanced activity in tumor invasion and metastasis via up - regulating the expression of VEGF or cooperating with VEGF.
出处
《安徽医药》
CAS
2009年第5期524-526,共3页
Anhui Medical and Pharmaceutical Journal
