摘要
目的观察款冬花及其有效部位与紫菀不同部位配伍后对止咳作用的影响,寻找款冬花与紫菀配伍中紫菀止咳的相须部位。方法通过小鼠氨水引咳实验观察款冬花、款冬花与紫菀配伍的止咳作用。结果款冬花、款冬花与紫菀的配伍均能减少氨水引咳小鼠的咳嗽次数,其中款冬花水提物及其90%醇沉部位止咳效果最好;配伍实验显示,紫菀30%醇提物及其90%醇溶部位与款冬并配伍后,对氨水引咳小鼠的止咳作用最为明显。结论款冬花水提物的止咳效果优于乙醇提取物;水提物中90%醇沉部位效果最好,为款冬花止咳作用的有效部位。紫菀30%乙醇提取物对款冬花止咳的增效作用优于其他溶剂;而其90%醇溶部位与款冬花配伍后止咳作用的增强效果最为显著,确定该部位为配伍中紫菀的相须部位。
Objective To search the antitussive part of Flos Farfarae （FF） and the reinforcement part of Radix Asteris （RA） in the paired drug （compound drug） of FF and RA. Methods Evaluating the antitussive effect by cough times of mice caused by ammonia. Results Both FF and the pair - drug of FF and RA can reduce the cough times of mice caused by ammonia . The aque-ous extract （AE） of FF and its part of insoluble in 90% ethanol （90% insol - part） showed the best antitussive effects. The compound group of 30% ethanol extract （30% - EE） of RA with AE of FF showed obvious effect, and the groups of the part of soluble in 90% ethanol （90% sol- part） of RA with FF （AE and 90% insol -part, respectively） also showed the best antitussive effects. Conclusion The AE of FF is more effective than its ethanol extracts, and the 90% insol - part of FF is the effective antitussive part. In compound drugs, the 30% - EE and the 90% sol - part of RA can greatly reinforce the antitussive effect of FF. According to the compatibility theory of traditional Chinese medicine, the 90% sol - part of RA should be the promotional part to FF in the paired drug.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2009年第5期1042-1044,共3页
Lishizhen Medicine and Materia Medica Research
基金
国家自然科学基金面上项目(No.30772702)
关键词
款冬花
有效部位
紫菀
配伍
相须部位
Flos Farfarae
Antitussive part
Radix Asteris
Compatibility
Promotional part
