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大黄对肠缺血致肝细胞损伤防治作用的研究 被引量:1

EXPERIMENTAL STUDIES ON EFFECT OF RHUBARB ON HEPATOCYTE INJURY AFTER INTESTINAL ISCHEMIA REPERFUSION
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摘要 目的:评价大黄对大鼠肠缺血所致肝细胞损伤的防治作用。方法:实验动物分为三组:假手术对照组,肠缺血再灌流组和肠缺血再灌流+大黄组。分别观察肝组织脂质过氧化物(LPO)、谷胱甘肽过氧化物酶(GSH-Px),肝线粒体呼吸功能以及肝脏形态学变化。结果:应用大黄能显著降低肝组织LPO,升高GSH-Px,降低肝线粒体内膜通透性以及减轻肝脏形态学变化。结论:大黄对肠缺血所致肝细胞损伤具有防治作用。 Aim: To evaluate the effect of rhubarb on hepatocyte injury after intestinal ischemia reperfusion in rats. Methods: All rats were divided into 3 groups: sham operation, intestinal ischemia reperfusion untreated and intestinal ischemia reperfusion rhubarb treated. Liver LPO,GSH-Px and respiratory functions of liver mitochondria were measured. In addition,morphological changes in liver were observed by light microscopy. Results: Treatment with rhubarb could significantly decrease liver LPO, elevate liver GSH-Px, reduce permeability damages in the inner membrane of liver mitochondria,as well as alleviate morphologic changes in liver. Conclusion:Rhubarb may have protective effect on hepatocyte injury after intestinal ischemia reperfusion in rats.
出处 《急诊医学》 CSCD 1998年第2期80-81,共2页
关键词 大黄 肠缺血 肝细胞损伤 药物疗法 休克 Rhubarb Intestinal ischemia Hepatocyte
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  • 1梁嵘,杨维益.大黄抗衰老作用的探讨——大黄对小鼠肝匀浆过氧化脂质的影响[J]天津中医,1988(06).

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