摘要
目的:分析本院药品不良反应(ADR)发生特点和一般规律,为临床合理用药提供参考。方法:对本院2004年～2008年收集到的397例ADR报告分别从患者年龄、性别、给药途经、ADR出现时间、ADR涉及药品种类、涉及器官或系统及具体临床表现等方面进行回顾性分析。结果:在397例ADR中,60岁以上患者和10岁以下的患者较多,占总例数的29.21%(116例)和16.88%(67例);涉及药品133种,抗菌药物居首位(30.88%),其次是抗肿瘤药;给药途经以静脉滴注为主(70.03%);临床表现以皮肤及其附件损害最常见(44.84%);严重的ADR有9例。结论:应高度重视ADR工作,加强合理用药特别是抗菌药物合理用药教育,慎用静脉注射剂,减少和避免ADR的发生。
OBJECTIVE： To analyze the characteristics and the regular pattern of adverse drug reactions （ADR） occurred in our hospital for references of clinical rational drug use. METHODS： A total of 397 ADR cases collected in our hospital from 2004 to 2008 were analyzed retrospectively in respect of patients＇ age and sex, routes of administration, ADR- occurring time, the kinds of drugs involved, ADR - involved organs or systems and clinical manifestations etc. RESULTS： Of the 397 ADR cases, 116 （29.21%） were patients aged above 60 years and 67 （16.88%） were children aged below 10 years. A total of 133 drugs were involved in the 397 ADR cases, leading the lead were antimicrobial agents （30.88 % ）, followed by antineoplastic agents. In terms of the route of administration, intravenous drip infusion showed the highest proportion at 70.03 %. 44.84 % of the ADRs manifested as Lesions of skin and appendages. There were nine severe ADR cases. CONCLUSION： Great importance should be attached to ADR monitoring and education on rational use of antimicrobial drugs. Moreover, the intravenous injections should be used with caution so as to reduce or avoid the occurrence of ADRs.
出处
《中国医院用药评价与分析》
2009年第5期389-391,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
药品不良反应
分析
合理用药
Adverse drug reactions
Analysis
Rational use of drug
