摘要
目的探讨异丙酚麻醉诱导睡眠治疗药物依赖性慢性失眠症的临床疗效。方法选择本科收治的30例药物依赖性慢性失眠症患者,在患者自愿并征得其书面同意后给予麻醉诱导睡眠治疗。采用匹兹堡睡眠质量指数,多导睡眠监测系统对患者治疗前、后的睡眠情况进行评估。结果患者经异丙酚麻醉诱导睡眠治疗后匹兹堡睡眠质量指数(PSQI)提示:在睡眠质量、入睡时间、睡眠效率及日间功能等睡眠指标上较治疗前有明显改善(P<0.05);多导睡眠图(PSG)结果表明:治疗后患者睡眠进程中的睡眠潜伏期缩短(P<0.05),总睡眠时间有所延长(P<0.05),而觉醒次数明显减少(P<0.01),相应的觉醒时间也明显减少(P<0.01);睡眠结构中的S1期睡眠较治疗前明显减少(P<0.01),S3期、S4期及REM期睡眠则明显增加(P<0.05),而S2期睡眠却未见明显变化。结论异丙酚麻醉诱导睡眠是短期内纠正慢性失眠患者睡眠债务行之有效的方法,为药物依赖性慢性失眠患者的临床治疗提供了可靠的选择。
Objective To evaluate the effect of treatment on chronic insomnia in hypnotic-depengdent by propofol anesthetize induce sleeping. Methods With patient＇s written informed consent,thirty chronic insomnia patients were cured by propofol anesthetize induce sleeping in our department. Polysomnography （PSG） recordings were conducted and scores of Pittsburgh sleep quality index（PSQI） were measured pre and post therapy. Results The score of PSQI suggested that there were 90% （27 cases）decreased more than 25% ,The patients were associated with a significantly higher responses to anesthetize duse sleeping therapy in ease of getting to sleep, quality of sleep,altering and behavioral integrity the following morning and gross score. Increased total sleep duration,decreased awake frequency and decreased awake duration was found after therapy with PSG while changed sleep architecture such as decreased S1 ,increased S3,S4 and the percentage of REM time was found. Conclusion The treatment by anesthetize induce sleeping may improve the sleep architecture of partial chronic insomnia patients in hypnotic-dependent especially effectively recover the sleep debt of the patient with in a short duration.
出处
《重庆医学》
CAS
CSCD
北大核心
2009年第10期1166-1167,1170,共3页
Chongqing medicine
