摘要
目的应用实验室免疫血清学方法监测合肥市流行性脑脊髓膜炎(流脑)患者感染状况以及易感人群免疫水平。方法采用回顾性诊断研究模式,采集合肥市辖区内医疗机构流脑监测病例急性期、恢复期双份血清,应用酶联免疫吸附试验分析患者流脑感染状况,通过急性期抗体浓度研究易感人群免疫水平。结果2005-2008年流脑流行季节流脑监测病例数186份,C群流脑病例检出率72.6%(135份)。易感人群急性期C群脑膜炎奈瑟菌(Nm)抗体浓度大于2μg/m l组监测病例数为29份,Nm抗体阳性病例1份,阳性率3.4%(1/29)。结论在合肥市流脑监测病例中流脑感染以C群Nm为主,易感人群急性期抗体浓度大于2μg/m l时有明显保护性。
Objective To determine the infection status and immtmity level of epidemic cerebrospinal meningitis in susceptible population in Hefei based on immunoserological surveillance. Methods The retrospective diagnostic approach was employed to analyze epidemic cerebrospinal meningitis （ECM） infection in susceptible population using ELISA based on the serum samples at the acute phase and convalescent period. The antibody concentration at the acute phase was used to study the immunity level in susceptible population. Results A total of 186 ECM cases were detected during the prevalent seasons from 2005 to 2008. The detection rate of group C was 72.6% （135）. The antibody concentration of group C Neisseria meningitis at the acute phase was greater than 2 μg/ml. The surveillance group consisting of 29 cases contained one positive case with the positive rate of 3.4% （1/29）. Conclusion Group C Neisseria meningitis constituted the predominant pathogens in ECM cases in the surveillance in Hefei. Significant protection was signaled in susceptible population when the antibody concentration was greater than 2μg/ml at the acute phase.
出处
《疾病监测》
CAS
2009年第3期178-180,共3页
Disease Surveillance
