摘要
探讨肾虚骨痛胶囊防治骨质疏松症的机理。方法：本实验以切除卵巢大鼠复制绝经后骨质疏松模型，观察该药对去势大鼠股骨无机元素含量及股骨骨灰重量的影响。实验分为模型组、肾虚骨痛胶囊大、小剂量组、骨疏康阳性对照组以及正常对照组。术后１周开始给药，持续 １２０天。结果： ３个给药组股骨无机元素 Ｃａ、 Ｐ、 Ｍｇ、 Ｚｎ、Ｃｕ、 Ｍｎ含量明显高于模型组（ Ｐ＜ ０． ０１），两个剂量组间有一定量效关系，与阳性对照组无显著性差异。大剂量组和骨疏康组股骨灰重明显高于模型组（ Ｐ＜ ０． ０１）。结论：肾虚骨痛胶囊确能对抗去势大鼠骨质改变，增加骨内无机元素含量，达到壮骨之效。
To explore the mechanism of Shenxu Gutong Capsule (SXGTC) in treating postmenopausal osteo porosis. Methods: Using ovariectomized rats as the model of postmentopausal osteoporosis, the effect of SXGTC on inorganic element content of femur and femoral ash weight of the model rats were surveyed. Animals were divided into model group, SXGTC high dose group, SXGTC low dose group, positive control group (treated with Gushukang) and normal control group. The medication began at one week after operation and lasting for 120 days. Results: The contents of inorganic elements, including Ca, P, Mg, Zn, Cu and Mn in the three medicated groups were higher than those of the model group (P<0.01). The effect of SXGTC was dose dependent. The difference between the SXGTC groups and the active control group was insignificant. The femoral ash weight of the SXGTC high dose group and the active control group was significantly higher than that of the model group (P < 0. 01). Conclusions: SXGTC could antagonize the rat's bony change caused by ovariectomy to increase the inorganic contents in bone, which may, in grneral, lead to a bone-strengthening effect.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1998年第2期101-103,共3页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家中医药管理局科研基金!922187
关键词
肾虚骨痛胶囊
骨质疏松
卵巢切除
无机元素
Shenxu Gutong Capsule
Osteoporosis
ovariectomy
inorganic elements
