摘要
采用微波辅助合成法快捷、高效地制备了系列咪唑类和吡啶类离子液体,并对其在亲核氟化中的应用进行了研究。结果表明,N-苄基吡啶四氟硼酸盐([bepy]BF4)是一种稳定性高、使用效果好的离子液体。在微波作用下,以N-苄基吡啶四氟硼酸盐和乙腈为共溶剂,以氟化铯为氟化试剂,高效合成了系列含氟化合物。在优化反应条件下,其收率为54.1%～76.3%,反应时间较常规油浴加热最好时可缩短50%以上。
Several ionic liquids of imidazole and pyridine salt were prepared efficiently under microwave-assisted, and their application in nucleophilic fluorination was studied. The results showed that [ bepy] BF4 is an excellent ionic liquid with good stability and solvency. Under the optimum conditions, [ bepy ] BF4 and CH3 CN as cosolvent, CsF as fluorinating agent, the yields of products were in the range of 54.4 % - 76.3 %, and the reaction time could be shortened by more than 50 % at the most compared with the conventional heating.
出处
《化学通报》
CAS
CSCD
北大核心
2009年第5期463-466,共4页
Chemistry
关键词
微波化学
离子液体
亲核氟化
卤素交换氟化
Microwave chemistry, Ionic liquid, Nucleophilic fluorination, Halogen-exchange fluorination
