摘要
目的探讨脑卒中后抑郁（PSD）患者的甲状腺功能动态变化及临床意义。方法采用抑郁自评量表将62例发病在24h以内的急性脑梗死患者分为单纯脑梗死组（CI组）和PSD组，分别在入院第2天、第7天、第14天及第21天测定游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）和促甲状腺素（TSH）水平。结果①入院第2天、第7天、第14天及第21天PSD组FT3水平均低于同期CI组。2组患者入院第7天FT3水平[分别为（2．04±0．53）ng／ml，（1．43±0．91）ng／ml]较入院第2天[分别为（1．28±0．19）ng/ml，（1．07±0．37）ng／m1]显著升高（P〈0．05）；入院第14天、第21天，PSD组FT3水平继续增加，CI组而与第7天差异不明显。②入院第2天、第7天PSD组FT4水平高于同期CI组。2组患者人院第14天的FT4水平[分别为（1．52±0．18）pg／ml，（1．57±0．31）pg/ml]均较第7天[分别为（2．09±0．26）pg／ml，（2．28±0．38）pg/ml]明显下降（P〈0．05）。③入院第2天PSD组TSH水平低于CI组（P〈0．05）。结论下丘脑-垂体-甲状腺轴功能变化在PSD发病机制中起重要作用。
Objective To investigate the clinical significances of thyroid function changes in patients with post-stroke depression（PSD）. Methods Sixty two cases with acute cerebral infarction （CI） were stratified into two groups by Zung self-rating depression scale, single cerebral infarct patients group （ CI group） and PSD group. Serum levels of FT3, FT4 and TSH of the patients were detected on 2 days ,Tdays, 14 clays and 21 days after admission. Results （1）On each time point after admission, FT3 levels in PSD group were lower than those in CI group. FT3 levels in the two groups on the 7 days were higher than those on 2 days（2.04 ±0.53 vs 1.28 ±0.19, 1.43 ±0.91 vs 1.07 ±0.37, P〈0. 05 ）. On the 14 and 21 days, levels of FT3 in the PSD group were continuously increased. （2）On the 2 clays and 7 days after admission, FT4 levels in PSD group were higher than those in CI group. FF4 levels in the two groups on the 14 clays were lower than those on 7 days（ 1.52 ± 0.18 vs 2.09 ± 0.26, 1.57 ± 0.31 vs 2.28 ± 0.38, P 〈 0.05 ）. （2）On the 2 days after admission, the TSH level in the PSD group were lower than that in CI group （2.02 ± 0.36 vs 2.27 ± 0.49, P 〈 0. 05 ）. Conclusion The results indicated that the hypothalamic-pituitary-thyroid axis plays important role in the pathogenesis of PSD.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2009年第2期120-121,共2页
Chinese Journal of Behavioral Medicine and Brain Science
关键词
卒中后抑郁
抑郁
甲状腺功能
Post-stroke depression（PSD）
Depression
Thyroid function
