摘要
目的探讨慢性乙型肝炎（CHB）患者胰岛素抵抗指数（HOMA-IR）与临床及病理特点的关系。方法对80例CHB患者进行血清谷丙转氨酶（ALT）、乙肝病毒载量（HBVDNA）及HOMA—IR的检测，并将其与肝组织病理进行相关性分析。结果胰岛素抵抗（IR）随着炎症活动度、纤维化程度的递增而加重。胰岛素水平（FINS）与HOMA-IR在G3级（15．24±7．41，3．51±1．91）高于G2级（10．33±6．28，2．25±1．39）；在S3期（16．65±6．46，3．79±1．50）高于S2期（9．06±4．61，2．02±1．11）。HOMA—IR与年龄、ALT呈正相关（r=0．273，0．224，P〈0．05）。结论CHB患者IR的发生、发展与年龄、肝组织炎症活动度和纤维化程度密切相关。
Objective To investigate the relationship between insulin resistance index （HOMA-IR） and the clinical pathology features in chronic hepatitis B（CHB） patients. Methods ALT and hepatitis B vires loading level and HOMA-IR were measured in 80 CHB patients. Correlation analysis was performed with pathological features of liver tissue. Result Insulin resistance （IR） was much more obvious in patients with severer degree of liver inflammation and fibrosis . HOMA-IR and the insulin level of CHB patients in G.3 grade（ 15.24 ± 7.41,3. 51 ± 1.91 ） and S3 stage （ 16. 65 ± 6. 46,3. 79 ± 1.50） were higher than those in G2 grade （ 10. 33 ± 6. 28,2. 25 ± 1.39） and S2 stage（9.06 ±4. 61,2. 02 ±1.11 ）. The HOMA-IR was positive correlated with the level of age and ALT. Conclusion The development of IR in CHB patients was correlated with age and the degree of liver inflammation and fibrosis.
出处
《中国医师杂志》
CAS
2009年第5期603-605,共3页
Journal of Chinese Physician
基金
国家重点基础研究发展计划（2007CB512800）
国家自然科学基金青年科学基金项目（30801039）
