摘要
目的观察丁基苯酞治疗急性脑梗死的临床效果。方法将60例急性脑梗死患者随机均分为两组,对照组常规使用疏血通、胞磷胆碱、阿司匹林治疗,观察组在对照组常规治疗基础上加用丁基苯酞口服,200mg/次,3次/d,14d后进行临床神经功能缺损评分,治疗前后测定部分活化凝血酶原时间(APTT)值。结果观察组有效率为86.67%,显效率为66.67%,死亡1例;对照组有效率为66.67%,显效率为36.67%,死亡2例。两组间有效率和显效率均有显著性差异(P<0.05),死亡率无显著性差异;两组的APTT值较治疗前均无显著性差异(P<0.05)。结论丁基苯酞治疗急性脑梗死有效,对死亡率和凝血功能无影响。
Objective To observe the therapeutic effect of dl- 3n- butylphthalide in the treatment of acute cerebral infarction. Methods 60 cases of cerebral infarction were randomly divided into two groups, 30 cases in each group. The patients in the control group were treated with Shuxuetong, eitieoline and aspirin, and the patients in the observation group were treated with the same medicine combined with dl- 3n- butyphthalide. Before treatment and after 14 d of treatment, the patients in the two groups were evaluated by the Clinical Neurological Impairment Sore. Blood APTT and mortality were recorded. Results There was significant difference in the Clinical Neurological Impairment Sore. The effective rate and the excellence rate were 86.67% and 66. 67% in the observation group respectively, and significantly higher than those（66.67%,36.67% ） of the control group. The mortality had no significant difference between the observational group （1/30） and the control group（2/30）. So did the variation of APTT. Conclusion dl-3n-butyphthalide to treat acute cerebral infarction can effectively improve neurologic impairment without significant effect on blood coagulation function and increasing mortality.
出处
《中国药业》
CAS
2009年第11期58-59,共2页
China Pharmaceuticals
关键词
丁基苯酞
脑梗死
疗效
凝血功能
dl - 3n - butyphthalide
cerebral infarction
therapeutic effect
blood coagulation function
