摘要
【目的】观察异丙酚静脉全麻下颅脑外伤术中过度通气对血清NSE的影响。[方法]80例急性颅脑外伤患者，手术中分别于正常通气（PETCO25．0kPa）、轻度（5．0-4．0kPa）、中度（3．5kPa）、重度（3．0kPa）过度通气并稳定15min后同步采集动脉血样行血清神经元特异性烯醇酶（NSE）测定。【结果】随着PETCO2的降低，患者血清NSE呈下降趋势，但至重度过度通气时，血清NSE显著升高（P〈0．01）。【结论】脑外伤术中过度通气可影响血清NSE含量，重度过度通气时血清NSE含量显著升高，脑损伤加重。故在颅脑手术麻醉中应避免重度过度通气。
[Objective]To assess the effects of hyperventilation on serum NSE in patients with acute brain trauma neurosurgery under general anesthesia. [Methods] Eighty acute brain trauma patients underwent intravenous general anesthesia and brain surgery. Mechanical ventilation was regulated to maintain PET CO2 at 5. 0KPa（normal ventilation）, 5. 0 - 4. 0KPa （slight hyperventilation）, 3.5KPa （moderate hyperventilation） and 3.0KPa（severe hyperventilation）during operation. Each level of PET CO2 was maintained for 15rain and then the radial arterial blood samples were taken simultaneously for serum NSE analysis. [Results] With the decline of PETCOz, serum NSE decreased. During severe hyperventilation, serum NSE increased significantly（ P 〈0.01）. [Conclusion] Severe hyperventilation can influence serum NSE level during acute brain trauma surgery, so it should not be used for brain surgery during anesthesia.
出处
《医学临床研究》
CAS
2009年第5期855-856,共2页
Journal of Clinical Research
