期刊文献+

脑梗塞和脑出血患者脑脊液肿瘤坏死因子的变化 被引量:3

Tumor Necrotic Factor Change of Cerebrospinal Fluid in Patients with Cerebral Infarction and Hemorrhage
下载PDF
导出
摘要 采用酶联免疫方法检测46例脑梗塞和37例脑出血患者的脑脊液和血清中TNF含量。结果显示两组脑脊液中TNF均明显高于对照组(P<0.01);脑出血组较脑梗塞组增高更明显。脑梗塞组血清TNF与对照组相比无差异;脑出血组血清TNF较对照组明显增高(P<0.01),但增高幅度低于脑脊液。两组患者脑脊液中TNF含量与发病初期收缩压呈显著正相关。提示TNF参与急性脑血管病脑组织损伤过程,亦可能是卒中发生的危险因素之一。 The applicatiion of enzyme linked immunoassay to determine the level of tumor necrotic factor (TNF)in cerebrospinal fluid (CSF) and serum of 46 cases with cerebral infarction (CI) and 37 cases with cerebral hemorrhage (CH) is presented in this paper.The result showed that in the two groups TNF in CSF was apparently higher than that of the control group ( p <0 01), and the rise in CH group was more distinct than in CI group, there was no difference in serum TNF between CI and control groups, while serum TNF of CH group was apparently higher than that of the control group ( P <0 01), but the range of rise is smaller than in CSF, in two groups of the cases TNF level in CSF had a hand in the process of brain tissue damage during cerebral infarction and hemorrhage, therefore it was proved to be one of the dangerous factors leading to acute cerebral diseases.
作者 李岚 颜晋辉
出处 《解放军医学高等专科学校学报》 1998年第2期11-13,共3页 Clinical Journal of Medical Officer
关键词 脑梗塞 脑出血 脑脊液 肿瘤坏死因子 cerebral infarction cerebral hemorrhage cerebrospinal fluid tumor necrotic factor
  • 相关文献

同被引文献7

  • 12,Dawson DA,Martion D,Hallenbeck JM.Inhibition of tumor necrosis factor-alphareduces local cerebral ischemic injury in the spontaneously hypertensive rat.NeurosciLett,1996,218(1):41
  • 23,Yamasaki Y,Itoyama Y,Kogure K.Involvement of cytokine production in pathogenesisof transient cerebral ischemic damage.Keio J Med,1996,45(3):225
  • 34,Liu T,Clark RK,Mcdonnell PC,et al.Tumor necrosis factor-α expression inischemic neurons.Stroke,1994,(7)25:1481
  • 4李岚 屠永华 赵光东.IL—1、TNF在局部脑缺血/再灌流中的表达[J].中国神经免疫学和神经病学杂志,1999,6(1):16-16.
  • 56,Sharief MK,Noori MA,Ciardi M,et al.Increased levels of circulating ICAM-1 inserum and cerebrospinal fluid of patients with active multiple sclerosis correlation withTNF-α and blood-brain barrier damage.J Neuroimmunnol,1993,43(1):15
  • 67,NawashiroH,MartinD,HallenbeckJM.Inhibitionoftumornecrosisfactorandameliorationofbraininfarctioninmice.JCerebBloodFlow,1997,17(2):229 (1999-08-30收稿2000-01-03修回)
  • 7李岚,屠永华,邵淑琴.炎性细胞因子与脑缺血[J].国外医学(脑血管疾病分册),1998,6(1):17-21. 被引量:23

引证文献3

二级引证文献15

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部