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腺苷蛋氨酸联合熊去氧胆酸治疗淤胆型病毒性肝炎的疗效观察 被引量:3

Effect of combination therapy of s-adenosylmethionine and ursodeoxycholic acid on patients with cholestatic virus hepatitis
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摘要 目的观察腺苷蛋氨酸联合熊去氧胆酸治疗肝内胆汁淤积性病毒性肝炎的临床疗效。方法选择急性淤胆型肝炎和慢性淤胆型肝炎患者132例,随机分为治疗组和对照组,每组各66例。治疗组给与腺苷蛋氨酸冻干粉针剂1000mg加入5%葡萄糖液250ml中静脉滴注,1次/d,熊去氧胆酸(尤思弗)250mg,2次/d口服,疗程均为4周。对照组采用门冬氨酸钾镁针剂30ml加入5%葡萄糖液250ml中静脉滴注,1次/d,疗程4周。观察症状、体征,并分别于2、4周复查肝功能,观察丙氨酸转氨酶(ALT)、天门冬氨酸转氨酶(AST)、血清总胆红素(STB)、血清结合胆红素(SCB)变化。结果两组治疗4周后乏力、腹胀、恶心、呕吐、肝区痛等症状均基本消失;治疗组的皮肤瘙痒的有效率、肝肿大回缩有效率以及肝功能主要指标下降幅度显著高于对照组,两组比较差异有统计学意义。结论腺苷蛋氨酸和熊去氧胆酸联合治疗无明显的毒副反应,其安全性和耐受性较好,是治疗淤胆型病毒性肝炎的有效方法。 Objective To observe the effect of combined application of s-adenosylmethionine and ursodeoxycholic acid in treating patients with cholestatic virus hepatitis.Methods One hundred and thirtytwo patients were enrolled and randomized into treated group(66 patients) and control groups(66 patients).The treated group received s-adenosylmethionine and ursodeoxycholic acid simultaneously for 4 weeks.The control group received potassium-magnesium-aspartate alone for 4 weeks.Their symptoms were observed and liver function were evaluated at 2 and 4 weeks.Results After 4 weks of treatment,the symptom improve ment rate in treatment group were significant higher than that in control group.The treatment group had a better effect in improving of the liver function.Conclusion Conmbined application of s-adenosylmethionine and ursodeoxycholic acid could enhance the therapeutic effect in treating cholestatic virus hepatitis.
机构地区 洛阳市中心医院
出处 《中国临床新医学》 2009年第4期405-407,共3页 CHINESE JOURNAL OF NEW CLINICAL MEDICINE
关键词 腺苷蛋氨酸 熊去氧胆酸 胆汁淤积 病毒性肝炎 治疗 S-adenosylmethionine Ursodeoxycholic acid Cholestatic virus hepatitis Therapy
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参考文献3

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  • 3Duerksen DR,Van Aerde JE,Gramlich L,et al.Intravenous ursodeoxycholic acid reduces cholestasis in parenterally fed newborn piglets[].Gastroenterology.1996

同被引文献28

  • 1傅继宁,肖冰,高克强.经脐单孔腹腔镜技术在肝胆外科疾病治疗中的应用[J].临床肝胆病杂志,2012,28(1):23-25. 被引量:11
  • 2Stieger B, Geier A. Genetic variations of bile salt transporters as pre- disposing factors for drug - induced cholestasis, intrahepatic cholesta- sis of pregnancy and therapeutic response of viral hepatitis [ J ]. Ex- pert Opin Drug Metab Toxicol, 2011,7:411 - 425.
  • 3Li J, Bardag - Gorce F, Oliva J, et al. Gene expression modifica- tions in the liver caused by binge drinking and S - adenosyl- methionine feeding. The role of epigenetic changes[ J]. Genes Nutr, 2010,5:169 - 179.
  • 4Tschimer A, yon Haehling S, Palus S, et al. Ursodeoxycholic acid treatment in a rat model of cancer cachexia J. J Cachexia Sarcope- nia Muscle, 2012,3 : 31 - 36.
  • 5Garcia-Compean D, Jaquez-Quintana JO, Lavalle-Gonzalez F J, et al. The pre- valence and clinical characteristics of glu- cose metabolism disorders in patients with liver cirrhosis. A prospective study[J]. An- nals of Hepatology, 2012,11(2):240-248.
  • 6Stieger B, Geier A. Genetic variations of bile salt transporters as predisposing fac- tors for drug-induced cholestasis, intra- hepatic cholestasis of pregnancy and thera- peutic response of viral hepatitis [J].Ex- pert Opin Drug Metab Toxicol,2011,7 (4):411-425.
  • 7Li J, Bardag-Goree F, Oliva J, et al. Gene expression modifications in the liver caused by binge drinking and Sadenos- ylmethionine feeding.The role of epigen- eric chanJ]. Gems Nutr,2010,5(2):169-179.
  • 8韩金岩,吴硕东,田雨.完全经脐单孔腹腔镜胆囊切除术30例临床应用分析[J].中华腔镜外科杂志(电子版),2009,2(1):16-19. 被引量:14
  • 9黄备建,毛枫,俞清,王希,李超伦,王文平.超声造影对提高肾错构瘤诊断率的价值[J].中华医学超声杂志(电子版),2010,7(6):15-17. 被引量:17
  • 10张霞.小组术前访视在腹腔镜胆囊切除术患者中的应用[J].中华现代护理杂志,2010,16(16):1920-1922. 被引量:13

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