摘要
目的以乳酸-羟基乙酸共聚物[poly(lactic-co-glycolic acid),PLGA]为材料,制备缓释局麻药利多卡因(Lido-caine,LID)-PLGA长效缓释微球。方法采用乳化溶媒挥发法制备微球;采用紫外分光光度法测定微球载药量、包封率和体外药物释放。结果纳米微球形态光滑圆整,球体大小均匀,微球粒径为(174.5±15.2)nm,微球载药量和包封率分别为12.48%和54.30%,微球体外释放符合Higuchi方程,半衰期t1/2=3.45d。结论LID-PLGA纳米微球具有明显缓释作用。
Objective To prepare LID-PLGA nanospheres （LID-PLGA-Ns） with poly（lactic-co-glycolic acid） （PLGA） for the study of the release properties in vitro. Methods The nanospheres were prepared by the solvent evaporation method. The drug-loading, encapsulation efficiency and release in vitro were determined by ultraviolet-visible spectrophotometry. Results The prepared LID-PLGA-Ns were even and uniform spheres with mean panicle size of （174.5± 15.2）rim in diameter. The drug loading and encapsulation efficiency were 12.48% and 34.30% , respectively. The in vitro release profile of nanospheres was found to agree with Higuchi equation, with tl/2 = 3.45 d . Conclusion The prepared nanospheres loaded with lidocaine are of slow-release function in vitro.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2009年第12期1155-1157,共3页
Journal of Third Military Medical University
基金
创伤
烧伤与复合伤国家重点实验室开放基金(200714)~~
