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红毛五加总甙的镇痛作用 被引量:13

ANALGESIC EFFECT OF TOTAL GLUCOSIDES OF ACANTHOPANAX GIRALDII HARMS
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摘要 红毛五加甙(TGA,ig200-800mg·kg-1)能显著抑制小鼠热板、扭体、嘶叫反应及大鼠甩尾反应。连续给药7d,镇痛作用无耐受现象。小鼠和大鼠icv20mg(相当ig有效剂量的1/10,可明显提高其痛阈。纳洛酮(2mg·kg-1)、利血平(4mg·kg-1)不影响TGA的镇痛作用。TGA还能明显降低大鼠足跖炎症组织中PGE的含量。结果提示,TGA具有镇痛作用,其作用部位可能在中枢,但可能不是通过兴奋阿片受体或影响脑内单胺类递质而发挥作用的;对PGE含量的影响。 Acanthopanax giraldii harms, a traditional Chinese herb, had been proved to possess analgesic effect. In this study, the total glucosides of acanthopanax giraldii harms (TGA) was used to investigate the postulated effect. TGA suppressed writhing, squeak and hot plate reaction of mice and tail flicking reaction of rats, at dose of 200-800 mg·kg-1. The peak time was 1.0-1.5 hours after drug administration. Results suggested that TGA possess analgesic effect. No tolerance of analgesic effect was found after daily ig administration of TGA 400 mg·kg-1 for 7 days in mice assayed with hot plate method. The pain threshold of rats and mice was elevated after icv TGA in a dose of 1/10 systemic effective dose. However, naloxone(2 mg·kg-1) and reserpine(4 mg·kg-1) didn't block TGA'analgesic effect. These results suggested that the site of analgesic action of TGA may be in the central nervous system, the opiate receptor and monoamine transmitters in the brain seem not to be involved in the analgesic action of TGA. It decreased the content of PGE in inflammatory tissue of rats. This action of TGA may play a role in the analgesic action of TGA.
出处 《中国药物依赖性杂志》 CAS CSCD 1998年第2期88-92,共5页 Chinese Journal of Drug Dependence
关键词 红毛五加总甙 镇痛 纳洛酮 利血平 total glucosides of acanthopanax giraldii harms analgesia naloxone reserpine PGE
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  • 1曲淑岩,药学学报,1982年,17卷,1期,12页
  • 2解汝泰,中华核医学杂志,1982年,2卷,1期,43页
  • 3徐叔云,药理实验方法学,1982年
  • 4团体著者,吉林医科大学学报,1976年,2期,24页
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  • 7邓虹珠,孙士勇,李淑玉.红毛五加的抗炎作用[J].第一军医大学学报,1992,12(2):127-131. 被引量:9

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