摘要
目的:探讨核转录因子κBp65(NF-κBp65)、血管内皮生长因子A(VEGF-A)和p53蛋白在直肠癌中的表达及在直肠癌淋巴结转移中的意义。方法:采用免疫组化SP法,对50例原发直肠癌组织中的NF-κBp65、VEGF-A和p53蛋白表达进行检测,结合有无淋巴结转移等临床病理资料进行统计学分析。结果:NF-κBp65、VEGF-A和p53在直肠癌中高表达(分别为66%、54%、58%),三者相互间具相关性(P<0.05);NF-κBp65、VEGF-A和p53阳性表达与直肠癌的淋巴结转移具显著相关性(P<0.05)。结论:高度表达NF-κBp65、VEGF-A和p53的直肠癌更易发生淋巴结转移,它们可作为直肠癌浸润、转移的分子学指标。
Objective To investigate the expressions and significances of nuclear factor-kappa Bp65 （NF- κBp65）, vascular endothelial growth factor-A （VEGF-A）, and p53 in rectal carcinoma. Methods Expressions of NF- κBp65, VEGF-A, and p53 protein in 50 patients with rectal carcinoma were measured by immunohistochemical method.And the relationship between the expressions and lymphatic metastasis was analyzed. Results NF-κBp65, VEGF-A, and p53 were highly expressed in rectal carcinoma （66%, 54%, and 58%）. There were positive correlation among the expressions of NF-KBp65, VEGF-A, and p53 （P 〈 0.05）. NF-κBp65, VEGF-A, and p53 were correlated with lymphatic metastasis （P 〈 0.05）. Conclusion Rectal carcinoma with highly expressed NF-κBp65, VEGF-A, and p53 was highly correlated with lymphatic metastasis, indicating that NF-κBp65, VEGF-A, and p53 can be the indicators for judging invasion and metastasis of rectal carcinoma.
出处
《实用医学杂志》
CAS
北大核心
2009年第10期1578-1580,共3页
The Journal of Practical Medicine
基金
广东省自然科学基金项目(编号:8151063201000034)
